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  The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

Oishi, I., Suzuki, H., Onishi, N., Takada, R., Kani, S., Ohkawara, B., et al. (2003). The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes to Cells, 8(7), 645-654. doi:10.1046/j.1365-2443.2003.00662.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8A10-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8A11-A
Genre: Journal Article
Alternative Title : Genes Cells

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 Creators:
Oishi, Isao, Author
Suzuki, Hiroaki, Author
Onishi, Nobuyuki, Author
Takada, Ritsuko, Author
Kani, Shuichi, Author
Ohkawara, Bisei, Author
Koshida, Ikure, Author
Suzuki, Kentaro, Author
Yamada, General, Author
Schwabe, Georg C.1, Author              
Mundlos, Stefan1, Author              
Shibuya, Hiroshi, Author
Takada, Shinji, Author
Minami, Yasuhiro, Author
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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 Abstract: Background: Ror2 is an orphan receptor, belonging to the Ror family of receptor tyrosine kinases. Although Ror2 has been shown to play crucial roles in developmental morphogenesis, the precise signalling events that Ror2 mediates remain elusive. Since Ror2 possesses an extracellular cysteine-rich domain (CRD) that resembles the Wnt-binding sites of the Frizzled (Fz) proteins, it is conceivable that Ror2 interacts with members of the Wnt family. Results: Both Ror2/ and Wnt5a/ mice exhibit dwarfism, facial abnormalities, short limbs and tails, dysplasia of lungs and genitals, and ventricular septal defects. In vitro binding assay revealed that Wnt5a binds to the CRD of Ror2. Furthermore, Ror2 associates via its CRD with rFz2, a putative receptor for Wnt5a. Interestingly, Wnt5a and Ror2 activate the non-canonical Wnt pathway, as assessed by activation of JNK in cultured cells and inhibition of convergent extension movements in Xenopus. Conclusions: Our findings indicate that Wnt5a and Ror2 interact physically and functionally. Ror2 may thus act as a receptor for Wnt5a to activate non-canonical Wnt signalling.

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Language(s): eng - English
 Dates: 2003-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 175335
ISI: 000183958500006
DOI: 10.1046/j.1365-2443.2003.00662.x
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Title: Genes to Cells
  Alternative Title : Genes Cells
Source Genre: Journal
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Pages: - Volume / Issue: 8 (7) Sequence Number: - Start / End Page: 645 - 654 Identifier: ISSN: 1356-9597