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  Comparative analysis of globin loci in pufferfish and man suggests a common origin of vertebrate globin loci and reveals a novel mammalian globin locus.

Gillemans, N., McMorrow, T., Tewari, R., Wai, A., Burgtorf, C., Drabek, D., et al. (2003). Comparative analysis of globin loci in pufferfish and man suggests a common origin of vertebrate globin loci and reveals a novel mammalian globin locus. Blood Cells Molecules and Diseases, 31(1), 161-161.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8A1D-1 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8A1E-0
Genre: Zeitschriftenartikel
Alternativer Titel : Blood Cells Mol. Dis.

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 Urheber:
Gillemans, Nynke, Autor
McMorrow, Tara, Autor
Tewari, Rita, Autor
Wai, Albert, Autor
Burgtorf, Carola1, Autor
Drabek, Dubravka, Autor
Ventress, Nicki, Autor
Langeveld, An, Autor
Higgs, Douglas, Autor
Tan-Un, Kian, Autor
Grosveld, Frank, Autor
Philipsen, Sjaak, Autor
Affiliations:
1Max Planck Society, ou_persistent13              

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Schlagwörter: -
 Zusammenfassung: To further our understanding of the regulation of vertebrate globin loci, we have isolated cosmids containing - and -globin genes from the pufferfish Fugu rubripes. By DNA FISH analysis we show that Fugu contains two distinct hemoglobin loci situated on separate chromosomes. One locus contains only -globin genes ( -locus) while the other also contains a -globin gene ( -locus). This is the first poikilothermic species analysed where the physical linkage of the - and -globin genes has been uncoupled, supporting a model in which the separation of the - and -globin loci has occurred through duplication of a locus containing both types of genes. Surveys for transcription factor binding sites and DNaseI hypersensitive site mapping of the Fugu -locus suggest that a strong distal Locus Control Region regulating the activity of the globin genes, as found in mammalian -globin clusters, may not be present in the Fugu -locus. Searching the human and mouse genome databases with the genes surrounding the pufferfish hemoglobin loci reveals that homologues of some of these genes are in close proximity to cytoglobin, a recently described novel member of the globin family. This provides evidence that duplication of the globin loci has occurred several times during evolution, resulting in the five human globin loci known to date, each encoding proteins with specific functions in specific cell types.

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Sprache(n): eng - English
 Datum: 2003-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 192446
ISI: 000184101400133
 Art des Abschluß: -

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Titel: Blood Cells Molecules and Diseases
  Alternativer Titel : Blood Cells Mol. Dis.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 31 (1) Artikelnummer: - Start- / Endseite: 161 - 161 Identifikator: ISSN: 1079-9796