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  Genome-wide array analysis of normal and malformed human hearts

Kaynak, B., von Heydebreck, A., Mebus, S., Seelow, D., Hennig, S., Vogel, J., et al. (2003). Genome-wide array analysis of normal and malformed human hearts. Circulation, 107(19), 2467-2474. doi:10.1161/01.CIR.0000066694.21510.E2.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8A44-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8A45-3
Genre: Journal Article
Alternative Title : Circulation

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 Creators:
Kaynak, Bogac1, Author
von Heydebreck, Anja1, Author
Mebus, Sigrun, Author
Seelow, Dominik2, Author              
Hennig, Steffen3, Author              
Vogel, Jan, Author
Sperling, Hans-Peter, Author
Pregla, Reinhard, Author
Alexi-Meskishvili, Vladimir, Author
Hetzer, Roland, Author
Lange, Peter E.1, Author
Vingron, Martin4, Author              
Lehrach, Hans3, Author              
Sperling, Silke3, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              
3Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
4Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Free keywords: heart defects, congenital, hypertrophy, atrium, ventricle, molecular biology
 Abstract: Background We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects, which account for the largest number of birth defects in humans, represent complex genetic disorders. As a consequence of the malformation, abnormal hemodynamic features occur and cause an adaptation process of the heart. Methods and Results The statistical analysis of our data suggests distinct gene expression profiles associated with tetralogy of Fallot, ventricular septal defect, and right ventricular hypertrophy. Applying correspondence analysis, we could associate specific gene functions to specific phenotypes. Furthermore, our study design allows the suggestion that alterations associated with primary genetic abnormalities can be distinguished from those associated with the adaptive response of the heart to the malformation (right ventricular pressure overload hypertrophy). We provide evidence for the molecular transition of the hypertrophic right ventricle to normal left ventricular characteristics. Furthermore, we present data on chamber-specific gene expression. Conclusions Our findings propose that array analysis of malformed human hearts opens a new window to understand the complex genetic network of cardiac development and adaptation. For detailed access, see the online-only Data Supplement. Data Supplement: Genome-Wide Array Analysis of Normal and Malformed Human Hearts: Supplementary Information (HTML page)

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Language(s): eng - English
 Dates: 2003-05-20
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 174662
ISI: 000183014500015
DOI: 10.1161/01.CIR.0000066694.21510.E2
 Degree: -

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Title: Circulation
  Alternative Title : Circulation
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 107 (19) Sequence Number: - Start / End Page: 2467 - 2474 Identifier: ISSN: 0009-7322