High rate of constitutional chromosomal rearrangements in apparently sporadic 
ALS

Meyer, T.; Alber, B.; Roemer, K.; Martin, T.; Kalscheuer, V. M.; Gottert, E.; Zang, K. D.; Ludolph, A. C.; Ropers, H. H.; Prudlo, J.

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High rate of constitutional chromosomal rearrangements in apparently sporadic ALS

Meyer, T., Alber, B., Roemer, K., Martin, T., Kalscheuer, V. M., Gottert, E., et al. (2003). High rate of constitutional chromosomal rearrangements in apparently sporadic ALS. Neurology, 60(8), 1348-1350.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8A66-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8A67-8

Genre: Journal Article

Alternative Title : Neurology

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Creators:
Meyer, T., Author
Alber, B., Author
Roemer, K., Author
Martin, T., Author
Kalscheuer, V. M.¹, Author
Gottert, E., Author
Zang, K. D., Author
Ludolph, A. C., Author
Ropers, H. H.², Author
Prudlo, J., Author

Affiliations:
1Chromosome Rearrangements and Disease (Vera Kalscheuer), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479642
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549

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Abstract: Of 85 patients with ALS, the authors identified 3 patients with balanced translocations and 2 patients with pericentric inversions, all affecting distinct chromosomal loci. The high rate of constitutional aberrations (5.9%) suggests that ALS is, in part, associated with recombination-based rearrangements of genomic sequences.

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Language(s): eng - English

Dates: Date issued: 2003-04-22

Publication Status: Issued

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Identifiers: eDoc: 127765
ISI: 000182489600025

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Title: Neurology

Alternative Title : Neurology

Source Genre: Journal

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Pages: - Volume / Issue: 60 (8) Sequence Number: - Start / End Page: 1348 - 1350 Identifier: ISSN: 0028-3878