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  Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis

Herr, A., Meunier, D., Muller, I., Rump, A., Fundele, R., Ropers, H.-H., et al. (2003). Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis. Developmental Dynamics, 226(4), 579-586. doi:10.1002/dvdy.10260.

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Genre: Journal Article
Alternative Title : Dev. Dyn.

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 Creators:
Herr, Alexander1, Author
Meunier, Dominique1, Author
Muller, Ines1, Author
Rump, Andreas, Author
Fundele, Reinald2, Author              
Ropers, Hans-Hilger2, Author              
Nuber, Ulrike A.2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Free keywords: T-box transcription factor; cleft palate; nasal septum; ankyloglossia
 Abstract: TBX22 belongs to the T-box family of transcription factors and was originally found in an in silico approach designed to identify new genes on the human Xq12-q21 region. Mutations in TBX22 have been reported in families with X-linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown. We have identified mouse Tbx22 and analyzed its expression during embryogenesis by reverse transcriptase-polymerase chain reaction and in situ hybridization. In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage. The localization in the tongue frenulum perfectly correlates with the ankyloglossia phenotype in CPX. Furthermore, we identified positionally conserved binding sites for transcription factors, two of which have been implicated previously in palatogenesis (MSX1, PRX2).

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Language(s): eng - English
 Dates: 2003-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 127628
ISI: 000181998700001
DOI: 10.1002/dvdy.10260
 Degree: -

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Title: Developmental Dynamics
  Alternative Title : Dev. Dyn.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 226 (4) Sequence Number: - Start / End Page: 579 - 586 Identifier: ISSN: 1058-8388