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  The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome

Schweiger, S., & Schneider, R. (2003). The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome. BioEssays, 25(4), 356-366. doi:10.1002/bies.10256.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8A79-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8A7A-D
Genre: Journal Article
Alternative Title : Bioessays

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 Creators:
Schweiger, Susann1, Author              
Schneider, Rainer1, Author              
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1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Abstract: Opitz BBB/G syndrome is a monogenic disorder that is characterized by malformations of the ventral midline. Investigations into the underlying genetic defects and the pathobiochemistry of this syndrome have already shed light on the mechanisms of both the physiological and the pathological development of the ventral midline, a complicated multistep process. Moreover, these studies have revealed the ubiquitin-dependent regulation of microtubule-associated phosphatase 2A, a central mechanism in many cellular processes. In this review, we summarize recent findings and speculate upon their implications for both medical and general research.

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Language(s): eng - English
 Dates: 2003-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 127847
ISI: 000181884100008
DOI: 10.1002/bies.10256
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Title: BioEssays
  Alternative Title : Bioessays
Source Genre: Journal
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Pages: - Volume / Issue: 25 (4) Sequence Number: - Start / End Page: 356 - 366 Identifier: ISSN: 0265-9247