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  Wnt3a plays a major role in the segmentation clock controlling somitogenesis

Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler, A., Kanzler, B., et al. (2003). Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Developmental Cell, 4(3), 395-406. doi:10.1016/S1534-5807(03)00055-8.

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Genre: Journal Article
Alternative Title : Dev Cell

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 Creators:
Aulehla, Alexander, Author
Wehrle, Christian, Author
Brand-Saberi, Beate, Author
Kemler, Rolf, Author
Gossler, Achim, Author
Kanzler, Benoit, Author
Herrmann, Bernhard G.1, Author              
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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 Abstract: The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/β-catenin signaling and the segmentation clock. Axin2, a negative regulator of the Wnt pathway, is directly controlled by Wnt/β-catenin and shows oscillating expression in the PSM, even when Notch signaling is impaired, alternating with Lfng expression. Moreover, Wnt3a is required for oscillating Notch signaling activity in the PSM. We propose that the segmentation clock is established by Wnt/β-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates.

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 Dates: 2003-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 173668
DOI: 10.1016/S1534-5807(03)00055-8
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Title: Developmental Cell
  Alternative Title : Dev Cell
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 4 (3) Sequence Number: - Start / End Page: 395 - 406 Identifier: ISSN: 1534-5807