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  Identification of immunorelevant genes from greater wax moth (Galleria mellonella) by a subtractive hybridization approach

Seitz, V., Clermont, A., Wedde, M., Hummel, M., Vilcinskas, A., Schlatterer, K., et al. (2003). Identification of immunorelevant genes from greater wax moth (Galleria mellonella) by a subtractive hybridization approach. Developmental and Comparative Immunology, 27(3), 207-215. doi:10.1016/S0145-305X(02)00097-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8AA6-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8AA7-7
Genre: Journal Article
Alternative Title : Dev. Comp. Immunol.

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 Creators:
Seitz, Volkhard1, Author              
Clermont, A., Author
Wedde, M., Author
Hummel, M., Author
Vilcinskas, A., Author
Schlatterer, K., Author
Podsiadlowski, L., Author
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: Galleria mellonella, lipopolysaccharide, subtractive hybridization, real-time PCR, innate immunity, gloverin, peptidoglycan recognition protein, toxin-2
 Abstract: In this study we have analyzed bacterial lipopolysaccharide (LPS) induced genes in hemocytes of the Lepidopteran species Galleria mellonella using subtractive hybridization, followed by suppressive PCR. We have found genes that show homologies to molecules, such as gloverin, peptidoglycan recognition proteins and transferrin known to be involved in immunomodulation after bacterial infection in other species. In addition, a few molecules previously not described in the innate immune reactions were detected, such as a RNA binding molecule and tyrosine hydroxylase. Furthermore, the full-length cDNA of a LPS-induced molecule with six toxin-2-like domains is described to be a promising candidate to further elucidate the relationship between toxin- and defensin-like domains in arthropod host defense.

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Language(s): eng - English
 Dates: 2003-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

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Title: Developmental and Comparative Immunology
  Alternative Title : Dev. Comp. Immunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 27 (3) Sequence Number: - Start / End Page: 207 - 215 Identifier: ISSN: 0145-305X