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  CORG: a database for COmparative Regulatory Genomics

Dieterich, C., Wang, H., Rateitschak, K., Luz, H., & Vingron, M. (2003). CORG: a database for COmparative Regulatory Genomics. Nucleic Acids Research, 31(1), 55-57.

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Genre: Journal Article
Alternative Title : Nucleic Acids Res.

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 Creators:
Dieterich, Christoph1, Author
Wang, H., Author
Rateitschak, K., Author
Luz, Hannes2, Author              
Vingron, Martin3, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
3Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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 Abstract: Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG—‘COmparative Regulatory Genomics’—database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.

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Language(s): eng - English
 Dates: 2003-01-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 175339
ISI: 000181079700010
 Degree: -

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Title: Nucleic Acids Research
  Alternative Title : Nucleic Acids Res.
Source Genre: Journal
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Pages: - Volume / Issue: 31 (1) Sequence Number: - Start / End Page: 55 - 57 Identifier: ISSN: 0305-1048