English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region

Sudbrak, R., Reinhardt, R., Hennig, S., Günther, E., & Walter, L. (2002). Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region. Immunogenetics, 54(10), 699-704.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B65-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B66-2
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Sudbrak, Ralf1, Author              
Reinhardt, Richard2, Author              
Hennig, Steffen1, Author              
Günther, Eberhard, Author
Walter, Lutz, Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              

Content

show
hide
Free keywords: mhc, evolution, comparative sequence analysis, rhesus macaque
 Abstract: The sequence-based map of a part of the rhesus macaque major histocompatibility complex (MHC) extended class II region is presented. The sequenced region encompasses 67,401 bp and contains the SACM2L, RING1, FABGL and KE4 genes, as well as the HTATSF1-like and ZNF-like pseudogenes. Similar to human, but different from rat and mouse, no class I genes are found in the SACM2L-RING1 interval. The rhesus macaque extended MHC class II region shows a high degree of conservation of exonic as well as intronic and intergenic sequences compared with the respective human region. It is concluded that this particular genomic organization of the extended class II region--i.e., the absence of class I genes and the presence of the HTATSF1-like and ZNF-like pseudogenes--can be traced back to a common ancestor of humans and rhesus macaques about 23 million years ago.

Details

show
hide
Language(s): eng - English
 Dates: 2002-12-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 24572
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Immunogenetics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 54 (10) Sequence Number: - Start / End Page: 699 - 704 Identifier: -