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  Prediction of temporal gene expression. Metabolic opimization by re-distribution of enzyme activities.

Klipp, E., Heinrich, R., & Holzhütter, H.-G. (2002). Prediction of temporal gene expression. Metabolic opimization by re-distribution of enzyme activities. European Journal of Biochemistry, 269(22), 1432-1033.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B73-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B74-2
Genre: Journal Article
Alternative Title : Eur J Biochem

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 Creators:
Klipp, Edda1, Author              
Heinrich, Reinhart, Author
Holzhütter, Hermann-Georg, Author
Affiliations:
1Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554              

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Free keywords: Evolutionary optimization. Mathematical modelling. Metabolic regulation. Gene expression.
 Abstract: A computational approach is used to analyse temporal gene expression in the context of metabolic regulation. It is based on the assumption that cells developed optimal adaptation strategies to changing environmental conditions. Time-dependent enzyme profiles are calculated which optimize the function of a metabolic pathway under the constraint of limited total enzyme amount. For linear model pathways it is shown that wave-like enzyme profiles are optimal for a rapid substrate turnover. For the central metabolism of yeast cells enzyme profiles are calculated which ensure long-term homeostasis of key metabolites under conditions of a diauxic shift. These enzyme profiles are in close correlation with observed gene expression data. Our results demonstrate that optimality principles help to rationalize observed gene expression profiles.

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Language(s): eng - English
 Dates: 2002-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 27131
 Degree: -

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Title: European Journal of Biochemistry
  Alternative Title : Eur J Biochem
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 269 (22) Sequence Number: - Start / End Page: 1432 - 1033 Identifier: -