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  Steps toward mapping the human vasculature by phage display

Arap, W., Kolonin, M. G., Trepel, M., Lahdenranta, J., Cardó-Vila, M., Giordano, R. J., et al. (2002). Steps toward mapping the human vasculature by phage display. Nature Medicine, 8(2), 121-127.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B7B-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B7C-1
Genre: Journal Article
Alternative Title : Nat Med

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 Creators:
Arap, Wadih, Author
Kolonin, Mikhail G., Author
Trepel, Martin, Author
Lahdenranta, Johanna, Author
Cardó-Vila, Marina, Author
Giordano, Ricardo J., Author
Mintz, Paul J., Author
Ardelt, Peter U., Author
Yao, Virginia J., Author
Vidal, Claudia I., Author
Chen, Limor, Author
Flamm, Anne, Author
Valtanen, Heli, Author
Weavind, Lisa M., Author
Hicks, Marshall E., Author
Pollock, Raphael E., Author
Botz, Gregory H., Author
Bucana, Corazon D., Author
Koivunen, Erkki, Author
Cahill, Dolores1, Author
Troncoso, Patricia, AuthorBaggerly, Keith A., AuthorPentz, Rebecca D., AuthorDo, Kim-Anh, AuthorLogothetis, Christopher J., AuthorPasqualin, Renata, Author more..
Affiliations:
1Max Planck Society, ou_persistent13              

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 Abstract: The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand–receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.

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Language(s): eng - English
 Dates: 2002-11-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 24729
 Degree: -

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Title: Nature Medicine
  Alternative Title : Nat Med
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 8 (2) Sequence Number: - Start / End Page: 121 - 127 Identifier: -