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  Beta-2 Adrenergic receptor gene variations and coping styles in twins

Busjahn, A., Freier, K., Faulhaber, H.-D., Li, G.-H., Rosenthal, M., Jordan, J., et al. (2002). Beta-2 Adrenergic receptor gene variations and coping styles in twins. Biological Psychology, 61(1 - 2), 97-109.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B93-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8B94-9
Genre: Journal Article
Alternative Title : Biol Psychol

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 Creators:
Busjahn, Andreas, Author
Freier, Kristina, Author
Faulhaber, Hans-Dieter, Author
Li, Guo-Hua, Author
Rosenthal, Magda, Author
Jordan, Jens, Author
Hoehe, Margret R.1, Author              
Timmermann, Bernd2, Author              
Luft, Friedrich C., Author
Affiliations:
1Genetic Variation, Haplotypes, and Genetics of Complex Disease (Margret Hoehe), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479651              
2Sequencing, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433559              

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Free keywords: Coping; Genetics; Environment; Twins
 Abstract: We tested the hypothesis that the beta-2 adrenergic receptor (beta-2 AR) gene locus, with known effects on blood pressure regulation, is also involved in psychological coping styles. 166 pairs of monozygotic (MZ) and dizygotic (DZ) twins and DZ twin parents were investigated. We found common genetic variance for the coping factor Emotional Coping and blood pressure. Using three microsatellites we found linkage between the beta-2 AR gene locus and the coping factor Active Coping. Using allele-specific PCR of all the single nucleotide polymorphisms (SNPs) in the gene causing amino acid substitutions we identified associations between the +491 G/A SNP and various coping factors. We conclude that the beta-2 AR gene is relevant to coping. These preliminary findings suggest a molecular genetic underpinning of the relationship between psychological and physiological phenotypes important to cardiovascular risk.

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Language(s): eng - English
 Dates: 2002-10-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 27658
 Degree: -

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Title: Biological Psychology
  Alternative Title : Biol Psychol
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 61 (1 - 2) Sequence Number: - Start / End Page: 97 - 109 Identifier: -