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  Molecular Phenotyping of Mouse Mutant Resources by RNA Expression Profiling

Beckers, J., Hoheisel, J., Mewes, W., Vingron, M., & Hrabé de Angelis, M. (2002). Molecular Phenotyping of Mouse Mutant Resources by RNA Expression Profiling. Current Genomics, 3(3), 121-129.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C40-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C41-8
Genre: Journal Article

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Beckers, J., Author
Hoheisel, J., Author
Mewes, W., Author
Vingron, M.1, Author              
Hrabé de Angelis, M., Author
Affiliations:
1Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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 Abstract: Microarray-based techniques allow us to visualize and quantify the expression of every single gene in any population of cells. In yeast the true potential of large-scale transcriptome analysis in identifying regulatory units and understanding gene function has already been demonstrated by evaluating expression profiles of a comprehensive group of mutants. We discuss the potential of DNA-chip technologies for the analysis of gene expression in complex organisms. The usefulness of transcriptome analysis for clinical purposes und diagnosis of cancers is already well established. We argue that microarray-based expression profiling will also be a useful tool for the analysis of gene function and approaches complementary to classical phenotypic description in mammals, particularly in regard of the large resources of mutant models that are currently being generated by gene-targeting and mutagenesis of the mouse genome. Experimental requirements and potential future directions are discussed.

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Language(s): eng - English
 Dates: 2002-03
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: eDoc: 27747
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Title: Current Genomics
Source Genre: Journal
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Pages: - Volume / Issue: 3 (3) Sequence Number: - Start / End Page: 121 - 129 Identifier: -