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  The genome sequence of Schizosaccharomyces pombe

Wood, V., Gwilliam, R., Rajandream, M. A., Lyne, M., Lyne, R., Stewart, A., et al. (2002). The genome sequence of Schizosaccharomyces pombe. Nature, 415(6874), 871-880.

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Wood, V., Author
Gwilliam, R., Author
Rajandream, M. A., Author
Lyne, M., Author
Lyne, R., Author
Stewart, A., Author
Sgouros, J., Author
Peat, N., Author
Hayles, J., Author
Baker, S., Author
Basham, D., Author
Bowman, S., Author
Brooks, K., Author
Brown, D., Author
Brown, S., Author
Chillingworth, T., Author
Churcher, C., Author
Collins, M., Author
Connor, R., Author
Cronin, A., Author
Davis, P., AuthorFeltwell, T., AuthorFraser, A., AuthorGentles, S., AuthorGoble, A., AuthorHamlin, N., AuthorHarris, D., AuthorHidalgo, J., AuthorHodgson, G., AuthorHolroyd, S., AuthorHornsby, T., AuthorHowarth, S., AuthorHuckle, E. J., AuthorHunt, S., AuthorJagels, K., AuthorJames, K., AuthorJones, L., AuthorJones, M., AuthorOdell, C., AuthorOliver, K., AuthorO'Neil, S., AuthorPearson, D., AuthorQuail, M. A., AuthorRabbinowitsch, E., AuthorRutherford, K., AuthorRutter, S., AuthorSaunders, D., AuthorSeeger, K., AuthorSharp, S., AuthorSkelton, J., AuthorSimmonds, M., AuthorSquares, R., AuthorStevens, K., AuthorTaylor, K., AuthorTaylor, R. G., AuthorTivey, A., AuthorWalsh, S., AuthorWarren, T., AuthorWhitehead, S., AuthorWoodward, J., AuthorVolckaert, G., AuthorAert, R., AuthorRobben, J., AuthorGrymonprez, B., AuthorWeltjens, I., AuthorVanstreels, E., AuthorRieger, M., AuthorSchäfer, M., AuthorMüller-Auer, S., AuthorGabel, C., AuthorFuchs, M., AuthorFritzc, C., AuthorHolzer, E., AuthorMoestl, D., AuthorHilbert, H., AuthorBorzym, K.1, Author           Langer, I.2, AuthorBeck, A.3, Author           Lehrach, H.4, Author           Reinhardt, R.5, Author           Pohl, T. M., AuthorEger, P., AuthorZimmermann, W., AuthorWedler, H., AuthorWambutt, R., AuthorPurnelle, B., AuthorGoffeau, A., AuthorCadieu, E., AuthorDréano, S., AuthorGloux, S., AuthorLelaure, V., AuthorMottier, S., AuthorGalibert, F., AuthorAves, S. J., AuthorXiang, Z., AuthorHunt, C., AuthorMoore, K., AuthorHurst, S. M., AuthorLucas, M., AuthorRochet, M., AuthorGaillardin, C., AuthorTallada, V. A., AuthorGarzon, A., AuthorThode, G., AuthorDaga, R. R., AuthorCruzado, L., AuthorJimenez, J., AuthorSánchez, M., AuthorDel Rey, F., AuthorBenito, J., AuthorDomínguez, A., AuthorRevuelta, J. L., AuthorMoreno, S., AuthorArmstrong, J., AuthorForsburg, S. L., AuthorCerrutti, L., AuthorLowe, T., AuthorMcCombie, W. R., AuthorPaulsen, I., AuthorPotashkin, J., AuthorShpakovski, G. V., AuthorUssery, D., AuthorBarrell, B. G., AuthorNurse, P., Author more..
1Mechanisms of Transcriptional Regulation (Sebastiaan H. Meijsing), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479641              
2Max Planck Society, ou_persistent13              
3Computing (Head: Donald Buczek/Peter Marquardt), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479667              
4Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
5High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              


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 Abstract: We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.


Language(s): eng - English
 Dates: 2002-02-21
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 24564
 Degree: -



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Title: Nature
Source Genre: Journal
Publ. Info: -
Pages: - Volume / Issue: 415 (6874) Sequence Number: - Start / End Page: 871 - 880 Identifier: -