The genome sequence of Schizosaccharomyces pombe

Wood, V.; Gwilliam, R.; Rajandream, M. A.; Lyne, M.; Lyne, R.; Stewart, A.; Sgouros, J.; Peat, N.; Hayles, J.; Baker, S.; Basham, D.; Bowman, S.; Brooks, K.; Brown, D.; Brown, S.; Chillingworth, T.; Churcher, C.; Collins, M.; Connor, R.; Cronin, A.; Davis, P.; Feltwell, T.; Fraser, A.; Gentles, S.; Goble, A.; Hamlin, N.; Harris, D.; Hidalgo, J.; Hodgson, G.; Holroyd, S.; Hornsby, T.; Howarth, S.; Huckle, E. J.; Hunt, S.; Jagels, K.; James, K.; Jones, L.; Jones, M.; Odell, C.; Oliver, K.; O'Neil, S.; Pearson, D.; Quail, M. A.; Rabbinowitsch, E.; Rutherford, K.; Rutter, S.; Saunders, D.; Seeger, K.; Sharp, S.; Skelton, J.; Simmonds, M.; Squares, R.; Stevens, K.; Taylor, K.; Taylor, R. G.; Tivey, A.; Walsh, S.; Warren, T.; Whitehead, S.; Woodward, J.; Volckaert, G.; Aert, R.; Robben, J.; Grymonprez, B.; Weltjens, I.; Vanstreels, E.; Rieger, M.; Schäfer, M.; Müller-Auer, S.; Gabel, C.; Fuchs, M.; Fritzc, C.; Holzer, E.; Moestl, D.; Hilbert, H.; Borzym, K.; Langer, I.; Beck, A.; Lehrach, H.; Reinhardt, R.; Pohl, T. M.; Eger, P.; Zimmermann, W.; Wedler, H.; Wambutt, R.; Purnelle, B.; Goffeau, A.; Cadieu, E.; Dréano, S.; Gloux, S.; Lelaure, V.; Mottier, S.; Galibert, F.; Aves, S. J.; Xiang, Z.; Hunt, C.; Moore, K.; Hurst, S. M.; Lucas, M.; Rochet, M.; Gaillardin, C.; Tallada, V. A.; Garzon, A.; Thode, G.; Daga, R. R.; Cruzado, L.; Jimenez, J.; Sánchez, M.; Del Rey, F.; Benito, J.; Domínguez, A.; Revuelta, J. L.; Moreno, S.; Armstrong, J.; Forsburg, S. L.; Cerrutti, L.; Lowe, T.; McCombie, W. R.; Paulsen, I.; Potashkin, J.; Shpakovski, G. V.; Ussery, D.; Barrell, B. G.; Nurse, P.

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The genome sequence of Schizosaccharomyces pombe

Wood, V., Gwilliam, R., Rajandream, M. A., Lyne, M., Lyne, R., Stewart, A., et al. (2002). The genome sequence of Schizosaccharomyces pombe. Nature, 415(6874), 871-880.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8C4E-E Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8C4F-C

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Wood, V., Autor
Gwilliam, R., Autor
Rajandream, M. A., Autor
Lyne, M., Autor
Lyne, R., Autor
Stewart, A., Autor
Sgouros, J., Autor
Peat, N., Autor
Hayles, J., Autor
Baker, S., Autor
Basham, D., Autor
Bowman, S., Autor
Brooks, K., Autor
Brown, D., Autor
Brown, S., Autor
Chillingworth, T., Autor
Churcher, C., Autor
Collins, M., Autor
Connor, R., Autor
Cronin, A., Autor
Davis, P., AutorFeltwell, T., AutorFraser, A., AutorGentles, S., AutorGoble, A., AutorHamlin, N., AutorHarris, D., AutorHidalgo, J., AutorHodgson, G., AutorHolroyd, S., AutorHornsby, T., AutorHowarth, S., AutorHuckle, E. J., AutorHunt, S., AutorJagels, K., AutorJames, K., AutorJones, L., AutorJones, M., AutorOdell, C., AutorOliver, K., AutorO'Neil, S., AutorPearson, D., AutorQuail, M. A., AutorRabbinowitsch, E., AutorRutherford, K., AutorRutter, S., AutorSaunders, D., AutorSeeger, K., AutorSharp, S., AutorSkelton, J., AutorSimmonds, M., AutorSquares, R., AutorStevens, K., AutorTaylor, K., AutorTaylor, R. G., AutorTivey, A., AutorWalsh, S., AutorWarren, T., AutorWhitehead, S., AutorWoodward, J., AutorVolckaert, G., AutorAert, R., AutorRobben, J., AutorGrymonprez, B., AutorWeltjens, I., AutorVanstreels, E., AutorRieger, M., AutorSchäfer, M., AutorMüller-Auer, S., AutorGabel, C., AutorFuchs, M., AutorFritzc, C., AutorHolzer, E., AutorMoestl, D., AutorHilbert, H., AutorBorzym, K.¹, Autor Langer, I.², AutorBeck, A.³, Autor Lehrach, H.⁴, Autor Reinhardt, R.⁵, Autor Pohl, T. M., AutorEger, P., AutorZimmermann, W., AutorWedler, H., AutorWambutt, R., AutorPurnelle, B., AutorGoffeau, A., AutorCadieu, E., AutorDréano, S., AutorGloux, S., AutorLelaure, V., AutorMottier, S., AutorGalibert, F., AutorAves, S. J., AutorXiang, Z., AutorHunt, C., AutorMoore, K., AutorHurst, S. M., AutorLucas, M., AutorRochet, M., AutorGaillardin, C., AutorTallada, V. A., AutorGarzon, A., AutorThode, G., AutorDaga, R. R., AutorCruzado, L., AutorJimenez, J., AutorSánchez, M., AutorDel Rey, F., AutorBenito, J., AutorDomínguez, A., AutorRevuelta, J. L., AutorMoreno, S., AutorArmstrong, J., AutorForsburg, S. L., AutorCerrutti, L., AutorLowe, T., AutorMcCombie, W. R., AutorPaulsen, I., AutorPotashkin, J., AutorShpakovski, G. V., AutorUssery, D., AutorBarrell, B. G., AutorNurse, P., Autor mehr..

Affiliations:
1Mechanisms of Transcriptional Regulation (Sebastiaan H. Meijsing), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479641
2Max Planck Society, ou_persistent13
3Computing (Head: Donald Buczek/Peter Marquardt), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479667
4Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550
5High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552

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Zusammenfassung: We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.

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Sprache(n): eng - English

Datum: Erschienen: 2002-02-21

Publikationsstatus: Erschienen

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Identifikatoren: eDoc: 24564

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Titel: Nature

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Seiten: - Band / Heft: 415 (6874) Artikelnummer: - Start- / Endseite: 871 - 880 Identifikator: -

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