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  How does tmRNA move through the ribosome?

Ivanov, P. V., Zvereva, M. I., Shpanchenko, O. V., Dontsova, O. A., Bogdanov, A. A., Aglyamova, G. V., et al. (2002). How does tmRNA move through the ribosome? FEBS Letters, 514(1), 55-59.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C6A-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C6B-C
Genre: Journal Article

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 Creators:
Ivanov, Pavel V.1, Author
Zvereva, Maria I.1, Author
Shpanchenko, Olga V., Author
Dontsova, Olga A., Author
Bogdanov, Alexey A., Author
Aglyamova, Galina V., Author
Lim, Valery I., Author
Teraoka, Yoshika1, Author
Nierhaus, Knud H.2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              

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Free keywords: tmRNA; Ribosome; Translation; Cross-linking; Site-directed mutagenesis
 Abstract: To test the structure of tmRNA in solution, cross-linking experiments were performed which showed two sets of cross-links in two different domains of tmRNA. Site-directed mutagenesis was used to search for tmRNA nucleotide bases that might form a functional analogue of a codon–anticodon duplex to be recognized by the ribosomal A-site. We demonstrate that nucleotide residues U85 and A86 from tmRNA are significant for tmRNA function and propose that they are involved in formation of a tmRNA element playing a central role in A-site recognition. These data are discussed in the frame of a hypothetical model that suggests a general scheme for the interaction of tmRNA with the ribosome and explains how it moves through the ribosome.

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Language(s): eng - English
 Dates: 2002-01-25
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 24714
 Degree: -

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Title: FEBS Letters
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 514 (1) Sequence Number: - Start / End Page: 55 - 59 Identifier: -