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  SpliceNest: visualizing gene structure and alternative splicing based on EST clusters

Coward, E., Haas, S. A., & Vingron, M. (2002). SpliceNest: visualizing gene structure and alternative splicing based on EST clusters. Trends in Genetics, 18(1), 53-55.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C7C-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C7D-6
Genre: Journal Article

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 Creators:
Coward, Eivind1, Author
Haas, Stefan A.1, Author
Vingron, Martin2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Free keywords: alternative splicing; expressed sequence tag; gene index; EST; SpliceNest; gene structrue; contig
 Abstract: Messenger RNA sequences, expressed sequence tags (ESTs), and, in particular, consensus sequences of clustered ESTs provide valuable information about splice variants of genes. We have mapped such (predicted) human mRNA sequences onto human genomic DNA to compute gene structure and splice variants. The results of this computation have been collected in a public database, SpliceNest, with a web-based, interactive graphical user interface. The quality of the presented data profits from previous assembly of ESTs and allows for analysis of gene structure and detection of splice variants in conjunction with the clones and libraries that indicated variants. A new, web-accessible database, SpliceNest, contains predicted human gene structure and splice variants derived from human mRNAs and coding sequences predicted from EST assemblies and mapped onto genomic DNA.

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Language(s): eng - English
 Dates: 2002-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 27794
 Degree: -

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Title: Trends in Genetics
Source Genre: Journal
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Pages: - Volume / Issue: 18 (1) Sequence Number: - Start / End Page: 53 - 55 Identifier: -