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  Variance stabilization and robust normalization for microarray gene expression data

von Heydebreck, A., Huber, W., Poustka, A., & Vingron, M. (2002). Variance stabilization and robust normalization for microarray gene expression data. In W. Härdle, & B. Rönz (Eds.), Proceedings in Computational Statistics (pp. 623-628). Heidelberg: Physika Verlag.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8CB8-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8CB9-D
Genre: Conference Paper

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 Creators:
von Heydebreck, A.1, Author
Huber, W., Author
Poustka, A.2, Author              
Vingron, M.3, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Evolution and Development (Albert Poustka), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479650              
3Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Free keywords: Gene Expression, Microarray, Robust Regression, Variance Stabilization
 Abstract: We introduce a statistical model for microarray gene expression data that comprises data calibration, the quantification of di erential gene expression, and the quantification of measurement error. In particular, we derive a transformation h for intensity measurements, and a di erence statistic 4h whose variance is approximately constant along the intensity range. The parametric form h(x) = arsinh(a + bx) is derived from a model of the variance-versus-mean dependence for microarray intensity data, using the method of variance stabilizing transformations. The parameters of h together with those of the calibration between experiments are estimated with a robust variant of maximum-likelihood estimation.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 27852
 Degree: -

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Title: COMPSTAT 2002 - Proceedings in Computational Statistics - 15th Symposium
Place of Event: Berlin
Start-/End Date: 2002-08-24 - 2002-08-28

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Title: Proceedings in Computational Statistics
Source Genre: Proceedings
 Creator(s):
Härdle, W., Editor
Rönz, B., Editor
Affiliations:
-
Publ. Info: Heidelberg : Physika Verlag
Pages: 69 pp. Volume / Issue: (/) Sequence Number: - Start / End Page: 623 - 628 Identifier: ISBN: 3-7908-1517-9