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  Construction and Analysis of a Human-Chimpanzee Comparative Clone Map

Fujiyama, A., Watanabe, H., Toyoda, A., Taylor, T. D., Itoh, T., Tsai, S.-F., et al. (2002). Construction and Analysis of a Human-Chimpanzee Comparative Clone Map. Science, 295(5552), 131-134.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8CC2-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8CC3-6
Genre: Journal Article

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 Creators:
Fujiyama, Asao, Author
Watanabe, Hidemi, Author
Toyoda, Atsushi, Author
Taylor, Todd D., Author
Itoh, Takehiko, Author
Tsai, Shih-Feng, Author
Park, Hong-Seog, Author
Yaspo, Marie-Laure1, Author              
Lehrach, Hans2, Author              
Chen, Zhu, Author
Fu, Gang, Author
Saitou, Naruya, Author
Osoegawa, Kazutoyo, Author
de Jong, Pieter J., Author
Suto, Yumiko, Author
Hattori, Masahira, Author
Sakaki, Yoshiyuki, Author
Affiliations:
1Human Chromosome 21 (Marie-Laure Yaspo), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479652              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 29216
 Degree: -

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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 295 (5552) Sequence Number: - Start / End Page: 131 - 134 Identifier: -