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  Validating Gene Clusterings by Selecting Informative Gene Ontology Terms with Mutual Information.

Validating Gene Clusterings by Selecting Informative Gene Ontology Terms with Mutual Information. Berlin/Heidelberg: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8CED-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8CEE-8
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fulltext.pdf (Any fulltext), 452KB
 
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 Creators:
Costa, Ivan G.1, Author              
de Souto, Marcilio C. P., Author
Schliep, Alexander1, Author              
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              

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Free keywords: cluster validation - external index - gene ontology - mutual information
 Abstract: We propose a method for global validation of gene clusterings. The method selects a set of informative and non-redundant GO terms through an exploration of the Gene Ontology structure guided by mutual information. Our approach yields a global assessment of the clustering quality, and a higher level interpretation for the clusters, as it relates GO terms with specific clusters. We show that in two gene expression data sets our method offers an improvement over previous approaches.

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Language(s): eng - English
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 Publication Status: Not specified
 Pages: -
 Publishing info: Berlin/Heidelberg : Springer
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