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  Diffusion imaging-based subdivision of the human hypothalamus: A magnetic resonance study with clinical implications

Schönknecht, P., Anwander, A., Petzold, F., Schindler, S., Knösche, T. R., Möller, H. E., et al. (2013). Diffusion imaging-based subdivision of the human hypothalamus: A magnetic resonance study with clinical implications. European Archives of Psychiatry and Clinical Neuroscience, 263(6), 497-508. doi:10.1007/s00406-012-0389-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8DAD-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B002-3
Genre: Journal Article

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Schoenknecht_2013_Diffusion.pdf (Publisher version), 804KB
 
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 Creators:
Schönknecht, Peter1, Author
Anwander, Alfred2, Author              
Petzold, Friederike1, Author
Schindler, Stephanie1, Author              
Knösche, Thomas R.3, Author              
Möller, Harald E.4, Author              
Hegerl, Ulrich1, Author
Turner, Robert5, Author              
Geyer, Stefan5, Author              
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Free keywords: Hypothalamus; Subdivision; Diffusion; MRI; In vivo
 Abstract: The hypothalamus and its subdivisions are involved in many neuropsychiatric conditions such as affective disorders, schizophrenia, or narcolepsy, but parcellations of hypothalamic subnuclei have hitherto been feasible only with histological techniques in postmortem brains. In an attempt to map subdivisions of the hypothalamus in vivo, we analyzed the directionality information from high-resolution diffusion-weighted magnetic resonance images of healthy volunteers. We acquired T1-weighted and diffusion-weighted scans in ten healthy subjects at 3 T. In the T1-weighted images, we manually delineated an individual mask of the hypothalamus in each subject and computed in the co-registered diffusion-weighted images the similarity of the principal diffusion direction for each pair of mask voxels. By clustering the similarity matrix into three regions with a k-means algorithm, we obtained an anatomically coherent arrangement of subdivisions across hemispheres and subjects. In each hypothalamus mask, we found an anterior region with dorsoventral principal diffusion direction, a posteromedial region with rostro-caudal direction, and a lateral region with mediolateral direction. A comparative analysis with microstructural hypothalamus parcellations from the literature reveals that each of these regions corresponds to a specific group of hypothalamic subnuclei as defined in postmortem brains. This is to our best knowledge the first in vivo study that attempts a delineation of hypothalamic subdivisions by clustering diffusion-weighted magnetic resonance imaging data. When applied in a larger sample of neuropsychiatric patients, a structural analysis of hypothalamic subnuclei should contribute to a better understanding of the pathogenesis of neuropsychiatric conditions such as affective disorders.

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Language(s): eng - English
 Dates: 2012-12-182013-01-042013-09-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00406-012-0389-5
PMID: 23287964
Other: Epub 2013
 Degree: -

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Title: European Archives of Psychiatry and Clinical Neuroscience
Source Genre: Journal
 Creator(s):
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Publ. Info: Berlin : Springer International
Pages: - Volume / Issue: 263 (6) Sequence Number: - Start / End Page: 497 - 508 Identifier: ISSN: 0940-1334
CoNE: https://pure.mpg.de/cone/journals/resource/954927622119