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  Generation of animals allowing the conditional inactivation of the Pax4 gene.

Kordowich, S., Serup, P., Collombat, P., & Mansouri, A. (2012). Generation of animals allowing the conditional inactivation of the Pax4 gene. Transgenic Research, 21(6), 1215-1220. doi:10.1007/s11248-012-9624-0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-6F94-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CEF1-3
Genre: Journal Article

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1587178.pdf (Publisher version), 949KB
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 Creators:
Kordowich, S.1, Author              
Serup, P., Author
Collombat, P., Author
Mansouri, A.1, Author              
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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Free keywords: Beta-cells Pancreas; Insulin; Knockout; Floxed allele; Diabetes
 Abstract: Pax4 belongs to the paired-box family of transcription factors. The analysis of loss- and gain-of-function mutant animals revealed that this factor plays a crucial role in the endocrine pancreas. Indeed, Pax4 is required for the genesis of insulin-producing beta-cells. Remarkably, the sole misexpression of Pax4 in glucagon-expressing cells is able to induce their regeneration, endow these with beta-cell features, and thereby counter chemically induced diabetes. However, the function of Pax4 in adult endocrine cells remains unclear. Herein, we report the generation of Pax4 conditional knockout mice that will allow the analysis of Pax4 function in mature beta-cells, as well as in the adult central nervous system.

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Language(s): eng - English
 Dates: 2012-06-212012-12
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s11248-012-9624-0
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Title: Transgenic Research
Source Genre: Journal
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Pages: - Volume / Issue: 21 (6) Sequence Number: - Start / End Page: 1215 - 1220 Identifier: -