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  Meiotic Prophase Requires Proteolysis of M Phase Regulators Mediated by the Meiosis-Specific APC/C-Ama1

Okaz, E., Argüello-Miranda, O., Bogdanova, A., Vinod, P. K., Lipp, J. J., Markova, Z., et al. (2012). Meiotic Prophase Requires Proteolysis of M Phase Regulators Mediated by the Meiosis-Specific APC/C-Ama1. CELL, 151(3), 603-618. doi:10.1016/j.cell.2012.08.044.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-7761-6 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-7762-4
Genre: Zeitschriftenartikel

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 Urheber:
Okaz, Elwy1, Autor
Argüello-Miranda, Orlando2, Autor              
Bogdanova, Aliona2, Autor              
Vinod, P. K.1, Autor
Lipp, Jesse J.1, Autor
Markova, Zuzana2, Autor              
Zagoriy, Ievgeniia2, Autor              
Novak, Bela1, Autor
Zachariae, Wolfgang2, Autor              
Affiliations:
1external, ou_persistent22              
2Zachariae, Wolfgang / Chromosome Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565176              

Inhalt

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Schlagwörter: ANAPHASE PROMOTING COMPLEX/CYCLOSOME; SYNAPTONEMAL COMPLEX-FORMATION; DOUBLE-STRAND BREAKS; SACCHAROMYCES-CEREVISIAE; MOLECULAR-BIOLOGY; YEAST MEIOSIS; BUDDING YEAST; FHA DOMAIN; PROTEIN; KINASE
 Zusammenfassung: Whereas proliferating cells enter M phase shortly after DNA replication, the first M phase of meiosis is preceded by an extended prophase in which homologous chromosomes undergo recombination. Exit from prophase I is controlled by the recombination checkpoint (RC), which, in yeast, represses the meiosis-specific transcription factor Ndt80 required for the expression of B-type cyclins and other M phase regulators. We show that an extended prophase I additionally requires the suppression of latent, mitotic cell-cycle controls by the anaphase-promoting complex (APC/C) and its meiosis-specific activator Ama1, which trigger the degradation of M phase regulators and Ndd1, a subunit of a mitotic transcription factor. ama1 Delta mutants exit from prophase I prematurely and independently of the RC, which results in recombination defects and chromosome missegregation. Thus, control of prophase I by meiotic mechanisms depends on the suppression of the alternative, mitotic mechanisms by a meiosis-specific form of the APC/C.

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Sprache(n): eng - Englisch
 Datum: 2012-10-26
 Publikationsstatus: Im Druck publiziert
 Seiten: 16
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000310529300016
DOI: 10.1016/j.cell.2012.08.044
 Art des Abschluß: -

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Titel: CELL
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Seiten: - Band / Heft: 151 (3) Artikelnummer: - Start- / Endseite: 603 - 618 Identifikator: ISSN: 0092-8674