English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain.

Kucherenko, M. M., Barth, J., Fiala, A., & Shcherbata, H. R. (2012). Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain. The EMBO Journal, 31(24), 4511-4523. doi:10.1038/emboj.2012.298.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-78C5-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-1E31-2
Genre: Journal Article

Files

show Files
hide Files
:
1606221.pdf (Publisher version), 4MB
Name:
1606221.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Kucherenko, M. M.1, Author              
Barth, J., Author
Fiala, A., Author
Shcherbata, H. R.1, Author              
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

Content

show
hide
Free keywords: -
 Abstract: Mammalian neuronal stem cells produce multiple neuron types in the course of an individual's development. Similarly, neuronal progenitors in the Drosophila brain generate different types of closely related neurons that are born at specific time points during development. We found that in the post-embryonic Drosophila brain, steroid hormones act as temporal cues that specify the cell fate of mushroom body (MB) neuroblast progeny. Chronological regulation of neurogenesis is subsequently mediated by the microRNA (miRNA) let-7, absence of which causes learning impairment due to morphological MB defects. The miRNA let-7 is required to regulate the timing of alpha'/beta' to alpha/beta neuronal identity transition by targeting the transcription factor Abrupt. At a cellular level, the ecdysone-let-7-Ab signalling pathway controls the expression levels of the cell adhesion molecule Fasciclin II in developing neurons that ultimately influences their differentiation. Our data propose a novel role for miRNAs as transducers between chronologically regulated developmental signalling and physical cell adhesion.

Details

show
hide
Language(s): eng - English
 Dates: 2012-11-162012-12-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/emboj.2012.298
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The EMBO Journal
  Other :
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 31 (24) Sequence Number: - Start / End Page: 4511 - 4523 Identifier: ISSN: 0261-4189
CoNE: /journals/resource/954925497061