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  PKCγ participates in food entrainment by regulating BMAL1.

Zhang, L. Y., Abraham, D., Lin, S. T., Oster, H., Eichele, G., Fu, Y. H., et al. (2012). PKCγ participates in food entrainment by regulating BMAL1. Proceedings of the National Academy of Sciences of the United States of America, 109(50), 20679-20684. doi:10.1073/pnas.1218699110.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-78ED-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-8130-9
Genre: Journal Article

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 Creators:
Zhang, L. Y., Author
Abraham, D.1, Author              
Lin, S. T., Author
Oster, H.2, Author              
Eichele, G.1, Author              
Fu, Y. H., Author
Ptacek, L. J., Author
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1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              
2Research Group of Circadian Rhythms, MPI for biophysical chemistry, Max Planck Society, ou_578594              

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 Abstract: Temporally restricted feeding (RF) can phase reset the circadian clocks in numerous tissues in mammals, contributing to altered timing of behavioral and physiological rhythms. However, little is known regarding the underlying molecular mechanism. Here we demonstrate a role for the gamma isotype of protein kinase C (PKCγ) in food-mediated entrainment of behavior and the molecular clock. We found that daytime RF reduced late-night activity in wild-type mice but not mice homozygous for a null mutation of PKCγ (PKCγ−/−). Molecular analysis revealed that PKCγ exhibited RF-induced changes in activation patterns in the cerebral cortex and that RF failed to substantially phase shift the oscillation of clock gene transcripts in the absence of PKCγ. PKCγ exerts effects on the clock, at least in part, by stabilizing the core clock component brain and muscle aryl hydrocarbon receptor nuclear translocator like 1 (BMAL1) and reducing its ubiquitylation in a deubiquitination-dependent manner. Taken together, these results suggest that PKCγ plays a role in food entrainment by regulating BMAL1 stability.

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Language(s): eng - English
 Dates: 2012-11-072012-12-11
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1218699110
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Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Pages: - Volume / Issue: 109 (50) Sequence Number: - Start / End Page: 20679 - 20684 Identifier: -