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Free keywords:
DOUBLE-STRANDED-RNA; INNATE IMMUNE-RESPONSE; INDUCIBLE GENE-I; ANTIVIRAL
RESPONSES; PATTERN-RECOGNITION; INTERFERON INDUCTION; 5'-TRIPHOSPHATE
RNA; GENOME REPLICATION; ADAPTER PROTEIN; VIRUS-INFECTIONRIG-I activation; dsRNA PAMPs; crystal and cocrystal X-ray structures;
Abstract:
A series of high-resolution crystal structures of RIG-I and RIG-I: dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.
