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  A structure-based model of RIG-I activation

Kolakofsky, D., Kowalinski, E., & Cusack, S. (2012). A structure-based model of RIG-I activation. RNA-A PUBLICATION OF THE RNA SOCIETY, 18(12), 2118-2127. doi:10.1261/rna.035949.112.

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 Creators:
Kolakofsky, Daniel1, Author
Kowalinski, Eva2, Author           
Cusack, Stephen1, Author
Affiliations:
1external, ou_persistent22              
2Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565144              

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Free keywords: DOUBLE-STRANDED-RNA; INNATE IMMUNE-RESPONSE; INDUCIBLE GENE-I; ANTIVIRAL RESPONSES; PATTERN-RECOGNITION; INTERFERON INDUCTION; 5'-TRIPHOSPHATE RNA; GENOME REPLICATION; ADAPTER PROTEIN; VIRUS-INFECTIONRIG-I activation; dsRNA PAMPs; crystal and cocrystal X-ray structures;
 Abstract: A series of high-resolution crystal structures of RIG-I and RIG-I: dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.

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Language(s): eng - English
 Dates: 2012-12
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000311276500002
DOI: 10.1261/rna.035949.112
 Degree: -

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Title: RNA-A PUBLICATION OF THE RNA SOCIETY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA : COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Pages: - Volume / Issue: 18 (12) Sequence Number: - Start / End Page: 2118 - 2127 Identifier: ISSN: 1355-8382