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  Towards a bottom-up reconstitution of bacterial cell division

Martos, A., Jimenez, M., Rivas, G., & Schwille, P. (2012). Towards a bottom-up reconstitution of bacterial cell division. Trends in Cell Biology, 22(12/Special Issue – Synthetic Cell Biology), 634-643. doi:org/10.1016/j.tcb.2012.09.003.

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 Creators:
Martos, A.1, Author              
Jimenez, M.2, Author
Rivas, G.2, Author
Schwille, P.1, Author              
Affiliations:
1Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565169              
2External Organizations, ou_persistent22              

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 Abstract: The components of the bacterial division machinery assemble to form a dynamic ring at mid-cell that drives cytokinesis. The nature of most division proteins and their assembly pathway is known. Our knowledge about the biochemical activities and protein interactions of some key division elements, including those responsible for correct ring positioning, has progressed considerably during the past decade. These developments, together with new imaging and membrane reconstitution technologies, have triggered the 'bottom-up' synthetic approach aiming at reconstructing bacterial division in the test tube, which is required to support conclusions derived from cellular and molecular analysis. Here, we describe recent advances in reconstituting Escherichia coil minimal systems able to reproduce essential functions, such as the initial steps of division (proto-ring assembly) and one of the main positioning mechanisms (Min oscillating system), and discuss future perspectives and experimental challenges.

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Language(s): eng - English
 Dates: 2012-12
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: org/10.1016/j.tcb.2012.09.003
 Degree: -

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Title: Trends in Cell Biology
  Other : Trends Cell Biol.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Elsevier Current Trends
Pages: - Volume / Issue: 22 (12/Special Issue – Synthetic Cell Biology) Sequence Number: - Start / End Page: 634 - 643 Identifier: ISSN: 0962-8924
CoNE: https://pure.mpg.de/cone/journals/resource/954925580131