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  Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence

Kershaw, J., Leuze, C., Aoki, I., Obata, T., Kanno, I., Ito, H., et al. (2013). Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence. NeuroImage, 70, 10-20. doi:10.1016/j.neuroimage.2012.12.036.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-7DCC-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-AD40-2
Genre: Journal Article

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 Creators:
Kershaw, Jeff1, 2, Author
Leuze, Christoph3, Author              
Aoki, Ichio1, Author
Obata, Takayuki4, Author
Kanno, Iwao1, Author
Ito, Hiroshi1, Author
Yamaguchi, Yuki2, Author
Handa, Hiroshi2, Author
Affiliations:
1Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan, ou_persistent22              
2School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan, ou_persistent22              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
4Research Centre for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan, ou_persistent22              

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Free keywords: Oscillating-gradient spin-echo; Apparent diffusion tensor; In vivo rat brain; Tissue microstructure; Effective diffusion-time; Restricted diffusion
 Abstract: As the oscillating gradient spin-echo sequence has shown promise as a means to probe tissue microstructure, it was applied here to diffusion-tensor imaging of in vivo rat brain. The apparent diffusion tensor (ADT) was estimated for motion-probing gradient (MPG) frequencies in the range 33.3-133.3Hz, and regions-of-interest (ROIs) in the corpus callosum (CC), visual cortex (VC), cerebellar white matter (CBWM) and cerebellar grey matter (CBGM) were selected for detailed analysis. There were substantial, approximately linear changes to the ADT with increasing MPG frequency for all four ROIs. All ROIs showed clear increases in mean diffusivity. CBWM had a substantial decrease in fractional anisotropy, whereas the CC and VC had minor increases of the same parameter. All eigenvalues of the ADT tended to increase with frequency for the CBWM, CBGM and VC, but only the principal eigenvalue increased strongly for the CC. On the other hand, there was no evidence that the orientation of the principal eigenvector varied systematically with MPG frequency for any of the ROIs. The relationship between the behaviour of the eigenvalues and the behaviours of the mean diffusivity and fractional anisotropy is investigated in detail. Pixelwise linear fits to the MD from individual animals found elevated changes across the cerebellum. The data acquired for this work encompassed a range of effective diffusion-times from 7.5ms down to 1.875ms, and some ideas on how the results might be used to extract quantitative information about brain tissue microstructure are discussed.

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Language(s): eng - English
 Dates: 2012-12-272013-04-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: BibTex Citekey: kershaw2012
DOI: 10.1016/j.neuroimage.2012.12.036
PMID: 23274188
Other: Epub 2012
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 70 Sequence Number: - Start / End Page: 10 - 20 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166