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  Compensatory hyperactivations as markers of latent working memory dysfunctions in obsessive-compulsive disorder

Henseler, I., Gruber, O., Kraft, S., Krick, C., Reith, W., & Falkai, P. (2008). Compensatory hyperactivations as markers of latent working memory dysfunctions in obsessive-compulsive disorder. Journal of Psychiatry & Neuroscience, 33(3), 209-215.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-8B4B-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-C164-4
Genre: Journal Article

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 Creators:
Henseler, Ilona1, 2, Author              
Gruber, Oliver1, 2, Author
Kraft, Susanne2, Author
Krick, Christoph3, Author
Reith, Wolfgang3, Author
Falkai, Peter1, Author
Affiliations:
1Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg-August-University, Goettingen, ou_persistent22              
2Cognitive Neuroscience Unit, Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, ou_persistent22              
3Department of Neuroradiology, Saarland University Hospital, Homburg, ou_persistent22              

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Free keywords: Obsessive–compulsive disorder; Memory; Magnetic resonance imaging; Cognition
 Abstract: Objective Behavioural studies have implicated working memory (WM) deficits in obsessive–compulsive disorder (OCD). However, findings are inconsistent, which could be explained by compensation strategies used by a subgroup of OCD patients. To test this hypothesis, we examined patients without a behavioural deficit in WM during performance of different WM tasks using functional magnetic resonance imaging (fMRI). Methods We scaned 11 patients and 11 matched control subjects while they performed 3 verbal and spatial item-recognition tasks. Results Patients and healthy subjects engaged the same set of brain regions. However, in direct comparison, the patients exhibited significantly greater task-related activation in several frontal and parietal brain areas known to underlie WM. Conclusion Patients without manifest WM deficits exhibit increased activation in frontal and parietal brain areas relative to healthy subjects during WM task performance. These hyperactivations may permit them to compensate for reduced efficiency of their WM systems and may thus serve as markers of latent WM dysfunctions.

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Language(s): eng - English
 Dates: 2008-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: -
 Degree: -

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Title: Journal of Psychiatry & Neuroscience
  Abbreviation : J Psychiatry Neurosci
Source Genre: Journal
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Publ. Info: Ottawa, Ont., Canada : Journal of Psychiatry and Neuroscience
Pages: - Volume / Issue: 33 (3) Sequence Number: - Start / End Page: 209 - 215 Identifier: ISSN: 1180-4882
CoNE: https://pure.mpg.de/cone/journals/resource/1180-4882