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  Novel Caspase-Suicide Proteins for Tamoxifen-Inducible Apoptosis

Chu, Y. Y., Senghaas, N., Köster, R. W., Wurst, W., & Kühn, R. (2008). Novel Caspase-Suicide Proteins for Tamoxifen-Inducible Apoptosis. Genesis, 46(10), 530-536.

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 Creators:
Chu, Y. Y., Author
Senghaas, N., Author
Köster, R. W., Author
Wurst, W.1, Author              
Kühn, R., Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: caspase; apoptosis; tamoxifen; cell ablation; estrogen receptor
 Abstract: Taking advantage of a mutant estrogen receptor ligand binding domain (ER T), we developed novel Caspase fusion proteins for inducible apoptosis. We show that Caspase-ERT2 fusion proteins become specifically activated by the synthetic ligand 4-OH-tamoxifen and rapidly induce apoptotic cell death in human, murine, and zebrafish cells. This novel tool for targeted cell ablation greatly facilitates the generation of disease models as well as developmental and regeneration studies in model organisms. genesis 46:530-536, 2008. (C) 2008 Wiley-Liss, Inc.

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Language(s): eng - English
 Dates: 2008-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 395615
ISI: 000260600100004
 Degree: -

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Title: Genesis
Source Genre: Journal
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Pages: - Volume / Issue: 46 (10) Sequence Number: - Start / End Page: 530 - 536 Identifier: ISSN: 1526-954X