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  Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion

Reichenberg, A., Kraus, T., Haack, M., Schuld, A., Pollmächer, T., & Yirmiya, R. (2002). Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion. Psychoneuroendocrinology, 27(8), 945-956.

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資料種別: 学術論文
その他のタイトル : Psychoneuroendocrinology

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 作成者:
Reichenberg, A1, 著者
Kraus, T1, 著者
Haack, M1, 著者
Schuld, A1, 著者
Pollmächer, T1, 著者
Yirmiya, R1, 著者
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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キーワード: endotoxin; cytokines; anorexia; food consumption
 要旨: This study examined the effects of endotoxin administration on food and water consumption in humans, and the associations between these changes and endotoxin-induced secretion of cytokines, cortisol, and fever. Twenty healthy male volunteers received an i.v. injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in two experimental sessions. Blood samples were collected hourly, and rectal temperature was monitored continuously. Food consumption was significantly reduced at 0-4 h and significantly elevated at 4-5 h after the endotoxin injection. Endotoxin administration had no significant effect on water consumption. Endotoxin-induced secretion of TNF-alpha and IL-6 was positively associated with the decrease in food consumption (r = 0.61 and 0.68), and negatively associated with the rebound increase in food consumption (r = -0.53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF- alpha and IL-6 are involved in endotoxin-induced anorexia in humans. (C) 2002 Elsevier Science Ltd. All rights reserve

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言語: eng - English
 日付: 2002-11
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): eDoc: 4034
ISI: 000179600500006
 学位: -

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出版物 1

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出版物名: Psychoneuroendocrinology
  出版物の別名 : Psychoneuroendocrinology
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 27 (8) 通巻号: - 開始・終了ページ: 945 - 956 識別子(ISBN, ISSN, DOIなど): ISSN: 0306-4530