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  Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression

Bschor, T., Adli, M., Baethge, C., Eichmann, U., Ising, M., Uhr, M., Modell, S., Künzel, H., Müller-Oerlinghausen, B., & Bauer, M. (2002). Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression. Neuropsychopharmacology, 27(3), 470-478.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A189-C 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A18A-A
資料種別: 学術論文
その他のタイトル : Neuropsychopharmacology

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 作成者:
Bschor, T1, 著者
Adli, M1, 著者
Baethge, C1, 著者
Eichmann, U1, 著者
Ising, M1, 著者
Uhr, M1, 著者
Modell, S1, 著者
Künzel, H1, 著者
Müller-Oerlinghausen, B1, 著者
Bauer, M1, 著者
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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キーワード: lithium augmentation; major depression; cortisol; ACTH; HPA system; DEX/CRH test; neuroendocrinology
 要旨: Lithium augmentation is a well established strategy for treatment-resistant depression. The exact mode of its action is unknown, but an enhancement of serotonergic transmission is hypothesized. The authors investigated changes in thehypothalamic-pituitary-adrenocorticaI (HPA) system during lithium augmentation and their correlation to clinical response by means of the combined dexamethasone/CRH test (DEX/CRH test). Thirty patients with unipolar major depressive episodes (DSM IV) who had not responded to an adequate trial with an antidepressant were assessed on the day before lithium augmentation (baseline) with the DEX/CRH test (pretreatment with 1.5 mg dexamethasone p.o. at 11 P.m. and CRH stimulation at 3 P.m. on the next day). Twenty-four patients were reassessed after response was determined or, in cases of non- response, four weeks after initiation of lithium augmentation. Response to lithium augmentation was measured by weekly ratings on the Hamilton Depression Rating Scale (HDRS 17-item version). Response was defined as a DeltaHDRS of greater than or equal to50% and an cndpoint score of <10. Patients had a significantly higher ACTH and cortisol response to CRH stimulation during lithium augmentation compared with the values at baseline. There was no difference in ACTH and cortisol reaction between responders and non-responders to lithium augmentation. This increase is in contrast to the known normalization of HPA-axis overdrive after treatment with a tricyclic antidepressant like amitriptyline. Because the effect was independent of response status we suggest that this increase reflects an effect of lithium that is independent from the psychopathological state or its change. This effect might be explained by the serotonergic effects of lithium. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc

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言語: eng - English
 日付: 2002-09
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: eDoc: 4096
ISI: 000177487000015
 学位: -

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出版物 1

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出版物名: Neuropsychopharmacology
  出版物の別名 : Neuropsychopharmacology
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 27 (3) 通巻号: - 開始・終了ページ: 470 - 478 識別子（ISBN, ISSN, DOIなど）: ISSN: 0893-133X