Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C., Azad, S., Bisogno, T., Rammes, G., Cascio, M., et al. (2002). The endogenous cannabinoid system controls extinction of aversive memories. Nature, 418(6897), 530-534.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A197-C Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A198-A
Genre: Zeitschriftenartikel
Alternativer Titel : Nature

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Marsicano, G1, Autor
Wotjak, CT1, Autor
Azad, SC1, Autor
Bisogno, T1, Autor
Rammes, G1, Autor
Cascio, MG1, Autor
Hermann, H1, Autor
Tang, JR1, Autor
Hofmann, C1, Autor
Zieglgänsberger, W1, Autor
Di Marzo, V1, Autor
Lutz, B1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom(1). In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct. Despite the importance of extinction(2), its cellular mechanisms are largely unknown. The cannabinoid receptor 1 (CB1)(3) and endocannabinoids(4) are present in memory-related brain areas(5,6) and modulate memory(7,8). Here we show that the endogenous cannabinoid system has a central function in extinction of aversive memories. CB1-deficient mice showed strongly impaired short-term and long-term extinction in auditory fear-conditioning tests, with unaffected memory acquisition and consolidation. Treatment of wild-type mice with the CB1 antagonist SR141716A mimicked the phenotype of CB1- deficient mice, revealing that CB1 is required at the moment of memory extinction. Consistently, tone presentation during extinction trials resulted in elevated levels of endocannabinoids in the basolateral amygdala complex,a region known to control extinction of aversive memories(9). In the basolateral amygdala, endocannabinoids and CB1 were crucially involved in long-term depression of GABA (gamma-aminobutyric acid)-mediated inhibitory currents. We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdal

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2002-08-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4119
ISI: 000177162800040
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Nature
  Alternativer Titel : Nature
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 418 (6897) Artikelnummer: - Start- / Endseite: 530 - 534 Identifikator: ISSN: 0028-0836