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  Nocturnal secretion of TSH and ACTH in male patients with depression and healthy controls

Peteranderl, C., Antonijevic, I., Steiger, A., Murck, H., Held, K., Frieboes, R., Uhr, M., & Schaaf, L. (2002). Nocturnal secretion of TSH and ACTH in male patients with depression and healthy controls. Journal of Psychiatric Research, 36(3), 189-196.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A1ED-C 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A1EE-A
資料種別: 学術論文
その他のタイトル : J. Psychiatr. Res.

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 作成者:
Peteranderl, C1, 著者
Antonijevic, IA1, 著者
Steiger, A1, 著者
Murck, H1, 著者
Held, K1, 著者
Frieboes, RM1, 著者
Uhr, M1, 著者
Schaaf, L1, 著者
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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キーワード: thyroid axis; adrenal axis; TSH; ACTH; affective disorder; sleep
 要旨: profound alterations of the hypothalamic-pituitary-thyroid (HPT) and the hypothalamic-pituitary-adrenal (HPA) systems at the hypophyseal level have been described in affective disorder. To precisely characterize the basal alterations of both axes during sleep. we simultaneously investigated sleep EEG and the secretion of thyrotropin. ACTH and cortisol in nine drug-free male patients with depression in comparison to 10 healthy age and sex matched controls. In depressed patients the nearly diametrical nocturnal secretion of thyrotropin and ACTH was disturbed by significantly blunted thyrotropin values (TSH AUC 51.96+/-5.68 vs. 87.23+/-13.63. P<0.05) and elevated ACTH values (ACTH AUC 1804+/-161 vs. 1538+/-130. P<0.05) compared to controls. Moreover, cross correlation analysis revealed a highly negative association of 0 lag between thyrotropin and ACTH and between thyrotropin and cortisol in the control sample, indicating a physiological nocturnal negative correlation of HPT and HPA system. In the patients sample these associations were weak and reached not statistical significance. Therefore, as a descriptive tool, the ratio TSH/ACTH revealed a significant group difference between controls and patients in the first half of the night (TSH/ACTH AUC 6.50+/-0.42 vs. 3.35+/-0.31. P<0.05). Sleep-EEG analysis showed a shortened REM latency, a decrease of stage 2 and an increase of awake time in the patients. Our data support the hypothesis that both hypophyseal hormones reflect a common dysregulation of both systems in depression probably due to impaired action of TRH-related corticotropin-release- inhibiting-factor (CRIF). The ratio TSH/ACTH might be a tool to characterize alterations of both the HPT and HPA axis in depression during the first half of the night, (C), 2002 Elsevier Science Ltd. All rights reserve

資料詳細

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言語: eng - English
 日付: 2002-05
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: eDoc: 4157
ISI: 000175643300010
 学位: -

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出版物 1

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出版物名: Journal of Psychiatric Research
  出版物の別名 : J. Psychiatr. Res.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 36 (3) 通巻号: - 開始・終了ページ: 189 - 196 識別子（ISBN, ISSN, DOIなど）: ISSN: 0022-3956