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  White matter development in adolescence: Diffusion tensor imaging and meta-analytic results

Peters, B. D., Szeszko, P. R., Radua, J., Ikuta, T., Gruner, P., DeRosse, P., et al. (2012). White matter development in adolescence: Diffusion tensor imaging and meta-analytic results. Schizophrenia Bulletin, 38(6), 1308-1317. doi:10.1093/schbul/sbs054.

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 Creators:
Peters, Bart D.1, 2, Author
Szeszko, Philip R.1, 2, Author
Radua, Joaquim3, 4, Author
Ikuta, Toshikazu1, 2, Author
Gruner, Patricia1, 2, Author
DeRosse, Pamela1, 2, Author
Zhang, Jian-Ping1, 2, Author
Giorgio, Antonio5, 6, Author
Qiu, Deqiang7, 8, Author
Tapert, Susan F.9, Author
Brauer, Jens10, Author           
Asato, Miya R.11, Author
Khong, P. L.7, Author
James, Anthony C.12, Author
Gallego, Juan A.1, 2, Author
Malhotra, Anil K.1, 2, Author
Affiliations:
1Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA, ou_persistent22              
2Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY, USA, ou_persistent22              
3Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
4Department of Statistics, Fundació per a la Investigació i la Docència Maria Angustias Giménez (FIDMAG), Centro de Investigación en Red de Salud Mental (CIBERSAM), Sant Boi de Llobregat, Spain, ou_persistent22              
5Nuffield Department Clinical Neurosciences, FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
6Department of Neurological, Neurosurgical and Behavioral Sciences, University of Siena, Italy, ou_persistent22              
7Department of Diagnostic Radiology, University of Hong Kong, China, ou_persistent22              
8Department of Radiology, Stanford University, CA, USA, ou_persistent22              
9Department of Psychiatry, VA San Diego Healthcare System, University of California San Diego, CA, USA, ou_persistent22              
10Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
11Department of Pediatrics, University of Pittsburgh, PA, USA, ou_persistent22              
12Department of Psychiatry, Warneford Hospital, University of Oxford, United Kingdom, ou_persistent22              

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Free keywords: Adolescence; Development; Diffusion tensor imaging; Superior longitudinal fasciculus; Verbal fluency; Working memory
 Abstract: Background

In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence.

Methods

DTI was performed in 78 healthy subjects aged 8–21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence.

Results

In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age.

Conclusions

These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.

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Language(s): eng - English
 Dates: 2012-03-052012-04-122012-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/schbul/sbs054
PMID: 22499780
PMC: PMC3494037
Other: Epub 2012
 Degree: -

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Title: Schizophrenia Bulletin
  Other : Schizophr. Bull.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Rockville, MD : U.S. Dept. of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration
Pages: - Volume / Issue: 38 (6) Sequence Number: - Start / End Page: 1308 - 1317 Identifier: ISSN: 0586-7614
CoNE: https://pure.mpg.de/cone/journals/resource/954925532975