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  How preparation changes the need for top–down control of the basal ganglia when inhibiting premature actions

Jahfari, S., Verbruggen, F., Frank, M. J., Waldorp, L. J., Colzato, L., Ridderinkhof, K. R., et al. (2012). How preparation changes the need for top–down control of the basal ganglia when inhibiting premature actions. The Journal of Neuroscience, 32(32), 10870-10878. doi:10.1523/JNEUROSCI.0902-12.2012.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-B689-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-FA84-E
Genre: Journal Article

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 Creators:
Jahfari, Sara1, 2, Author
Verbruggen, Frederick3, Author
Frank, Michael J.4, Author
Waldorp, Lourens J.1, Author
Colzato, Lorenza5, Author
Ridderinkhof, K. Richard1, 2, Author
Forstmann, Birte U.1, 2, 6, Author              
Affiliations:
1Department of Psychology, University of Amsterdam, the Netherlands, ou_persistent22              
2Cognitive Science Center Amsterdam, University of Amsterdam, the Netherlands, ou_persistent22              
3School of Psychology, University of Exeter, United Kingdom, ou_persistent22              
4Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, RI, USA, ou_persistent22              
5Institute for Psychological Research, Leiden University, the Netherlands, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Goal-oriented signals from the prefrontal cortex gate the selection of appropriate actions in the basal ganglia. Key nodes within this fronto-basal ganglia action regulation network are increasingly engaged when one anticipates the need to inhibit and override planned actions. Here, we ask how the advance preparation of action plans modulates the need for fronto-subcortical control when a planned action needs to be withdrawn. Functional magnetic resonance imaging data were collected while human participants performed a stop task with cues indicating the likelihood of a stop signal being sounded. Mathematical modeling of go trial responses suggested that participants attained a more cautious response strategy when the probability of a stop signal increased. Effective connectivity analysis indicated that, even in the absence of stop signals, the proactive engagement of the full control network is tailored to the likelihood of stop trial occurrence. Importantly, during actual stop trials, the strength of fronto-subcortical projections was stronger when stopping had to be engaged reactively compared with when it was proactively prepared in advance. These findings suggest that fronto-basal ganglia control is strongest in an unpredictable environment, where the prefrontal cortex plays an important role in the optimization of reactive control. Importantly, these results further indicate that the advance preparation of action plans reduces the need for reactive fronto-basal ganglia communication to gate voluntary actions.

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Language(s): eng - English
 Dates: 2012-05-302012-02-242012-06-192012-08-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.0902-12.2012
PMID: 22875921
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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 32 (32) Sequence Number: - Start / End Page: 10870 - 10878 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187