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  Motor matters: Tackling heterogeneity of Parkinson’s disease in functional MRI studies

Holiga, Š., Mueller, K., Möller, H. E., Sieger, T., Schroeter, M. L., Vymazal, J., et al. (2013). Motor matters: Tackling heterogeneity of Parkinson’s disease in functional MRI studies. PLoS One, 8(2): e56133. doi:10.1371/journal.pone.0056133.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-B692-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F3A9-B
Genre: Journal Article

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Holiga_2013_Motor.pdf (Publisher version), 374KB
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 Creators:
Holiga, Štefan1, Author              
Mueller, Karsten1, Author              
Möller, Harald E.1, Author              
Sieger, Tomáš2, 3, Author
Schroeter, Matthias L.4, Author              
Vymazal, Josef5, Author
Růžička, Evžen2, Author
Jech, Robert2, Author
Maurits, Natasha M.6, Contributor
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
3Department of Cybernetics, Czech Technical University, Prague, Czech Republic, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Department of Radiology, Na Homolce Hospital, Prague, Czech Republic, ou_persistent22              
6University Medical Center Groningen, the Netherlands, ou_persistent22              

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 Abstract: To tackle the heterogeneity of Parkinson’s disease symptoms, most functional imaging studies tend to select a uniform group of subjects. We hypothesize that more profound considerations are needed to account for intra/inter-subject clinical variability and possibly for differing pathophysiological processes. Twelve patients were investigated using functional magnetic resonance imaging during visually-guided finger tapping. To account for disease heterogeneity, the motor score and individual symptom scores from the Unified Parkinson’s Disease Rating Scale (UPDRS-III) were utilized in the group-level model using two approaches either as the explanatory variable or as the effect of interest. Employment of the UPDRS-III score and symptom scores was systematically tested on the resulting group response to the levodopa challenge, which further accentuated the diversity of the diseased state of participants. Statistics revealed a bilateral group response to levodopa in the basal ganglia. Interestingly, systematic incorporation of individual motor aspects of the disease in the modelling amended the resulting activity patterns conspicuously, evidencing a manifold amount of explained variability by the particular score. In conclusion, the severity of clinical symptoms expressed in the UPDRS-III scores should be considered in the analysis to attain unbiased statistics, draw reliable conclusions and allow for comparisons between research groups studying Parkinson’s disease using functional magnetic resonance imaging.

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Language(s): eng - English
 Dates: 2012-10-012013-01-052013-02-13
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMC: 3572025
PMID: 23418522
Other: Epub 2013
DOI: 10.1371/journal.pone.0056133
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (2) Sequence Number: e56133 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850