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  Influences of skull segmentation inaccuracies on EEG source analysis

Lanfer, B., Scherg, M., Dannhauer, M., Knösche, T. R., Burger, M., & Wolters, C. H. (2012). Influences of skull segmentation inaccuracies on EEG source analysis. NeuroImage, 62(1), 418-431. doi:10.1016/j.neuroimage.2012.05.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-B6EE-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CD52-A
Genre: Journal Article

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Lanfer_2012_Influences.pdf (Publisher version), 3MB
 
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 Creators:
Lanfer, B.1, 2, Author
Scherg, M.2, Author
Dannhauer, Moritz3, Author              
Knösche, Thomas R.3, Author              
Burger, M.4, Author
Wolters, C. H.1, Author
Affiliations:
1Institute for Biomagnetism and Biosignal Analysis, Münster University, Germany, ou_persistent22              
2BESA GmbH, Gräfelfing, Germany, ou_persistent22              
3Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
4Institute for Computational and Applied Mathematics, Münster University, Germany, ou_persistent22              

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Free keywords: Skull modeling; EEG; Forward problem; Source reconstruction; Finite element model
 Abstract: The low-conducting human skull is known to have an especially large influence on electroencephalography (EEG) source analysis. Because of difficulties segmenting the complex skull geometry out of magnetic resonance images, volume conductor models for EEG source analysis might contain inaccuracies and simplifications regarding the geometry of the skull. The computer simulation study presented here investigated the influences of a variety of skull geometry deficiencies on EEG forward simulations and source reconstruction from EEG data. Reference EEG data was simulated in a detailed and anatomically plausible reference model. Test models were derived from the reference model representing a variety of skull geometry inaccuracies and simplifications. These included erroneous skull holes, local errors in skull thickness, modeling cavities as bone, downward extension of the model and simplifying the inferior skull or the inferior skull and scalp as layers of constant thickness. The reference EEG data was compared to forward simulations in the test models, and source reconstruction in the test models was performed on the simulated reference data. The finite element method with high-resolution meshes was employed for all forward simulations. It was found that large skull geometry inaccuracies close to the source space, for example, when cutting the model directly below the skull, led to errors of 20 mm and more for extended source space regions. Local defects, for example, erroneous skull holes, caused non-negligible errors only in the vicinity of the defect. The study design allowed a comparison of influence size, and guidelines for modeling the skull geometry were concluded.

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Language(s): eng - English
 Dates: 2012-05-042012-05-112012-08-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2012.05.006
PMID: 22584227
Other: Epub 2012
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 62 (1) Sequence Number: - Start / End Page: 418 - 431 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166