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  Separation of indocyanine green boluses in the human brain and scalp based on time-resolved in-vivo fluorescence measurements

Jelzow, A., Wabnitz, H., Obrig, H., Macdonald, R., & Steinbrink, J. (2012). Separation of indocyanine green boluses in the human brain and scalp based on time-resolved in-vivo fluorescence measurements. Journal of Biomedical Optics, 17(5): 057003. doi:10.1117/1.JBO.17.5.057003.

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Jelzow, Alexander1, Author
Wabnitz, Heidrun1, Author
Obrig, Hellmuth2, 3, 4, Author           
Macdonald, Rainer1, Author
Steinbrink, Jens3, Author
Affiliations:
1Physikalisch-Technische Bundesanstalt, Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 Abstract: Non-invasive detection of fluorescence from the optical tracer indocyanine green is feasible in the adult human brain when employing a time-domain technique with picosecond resolution. A fluorescence-based assessment may offer higher signal-to-noise ratio when compared to bolus tracking relying on changes in time-resolved diffuse reflectance. The essential challenge is to discriminate the fluorescence originating from the brain from contamination by extracerebral fluorescence and hence to reconstruct the bolus kinetics; however, a method to reliably perform the necessary separation is missing. We present a novel approach for the decomposition of the fluorescence contributions from the two tissue compartments. The corresponding sensitivity functions pertaining to the brain and to the extracerebral compartment are directly derived from the in-vivo measurement. This is achieved by assuming that during the initial and the late phase of bolus transit the fluorescence signal originates largely from one of the compartments. Solving the system of linear equations allows one to approximate time courses of a bolus for each compartment. We applied this method to repetitive measurements on two healthy subjects with an overall 34 boluses. A reconstruction of the bolus kinetics was possible in 62% of all cases.

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Language(s): eng - English
 Dates: 2012-05-042012-05
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1117/1.JBO.17.5.057003
PMID: 22612142
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Title: Journal of Biomedical Optics
Source Genre: Journal
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Publ. Info: Bellingham, WA : Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
Pages: - Volume / Issue: 17 (5) Sequence Number: 057003 Start / End Page: - Identifier: ISSN: 1083-3668
CoNE: https://pure.mpg.de/cone/journals/resource/954925607859