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  Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood

Lövden, M., Schaefer, S., Noack, H., Bodammer, N. C., Kühn, S., Heinze, H.-J., et al. (2012). Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood. Neurobiology of Aging, 33(3), 620.e9-620.e22. doi:10.1016/j.neurobiolaging.2011.02.013.

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Loevden_2012_Spatial.pdf (Publisher version), 2MB
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 Creators:
Lövden, Martin1, 2, 3, Author
Schaefer, Sabine1, Author
Noack, Hannes1, Author
Bodammer, Nils Christian1, Author
Kühn, Simone4, 5, Author              
Heinze, Hans-Jochen6, 7, Author
Düzel, Emrah7, 8, Author
Bäckman, Lars1, 3, Author
Lindenberger, Ulman1, Author
Affiliations:
1Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
2Department of Psychology, Lund University, Lund, Sweden, ou_persistent22              
3Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden, ou_persistent22              
4Department Psychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634564              
5Department of Experimental Psychology, Ghent University, Ghent, Belgium, ou_persistent22              
6Department of Neurology, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, ou_persistent22              
7DZNE (German Centre for Neurodegenerative Disorders), Magdeburg, Germany, ou_persistent22              
8Institute of Cognitive Neuroscience, University College London, London, UK, ou_persistent22              

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Free keywords: Cognitive aging; Cognitive training; Hippocampus; Plasticity; Spatial navigation
 Abstract: It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.

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Language(s): eng - English
 Dates: 2011-02-032010-04-092011-02-162011-04-162012-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 33 (3) Sequence Number: - Start / End Page: 620.e9 - 620.e22 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902