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  A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus

Uddén, J., & Bahlmann, J. (2012). A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 367(1598), 2023-2032. doi:10.1098/rstb.2012.0009.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-B90F-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F9FF-6
Genre: Journal Article

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Udden_2012_Rostro.pdf (Publisher version), 463KB
 
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 Creators:
Uddén, Julia1, 2, 3, Author
Bahlmann, Jörg4, 5, Author              
Affiliations:
1Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands, ou_persistent22              
2Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
3Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
4Helen Wills Neuroscience Institute, University of California, Berkely, CA, USA, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Sequence processing; Language; Cognitive control; Inferior frontal gyrus; Lateral prefrontal cortex
 Abstract: In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC.

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Language(s): eng - English
 Dates: 2012-06-112012-07-19
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1098/rstb.2012.0009
PMID: 22688637
PMC: PMC3367683
 Degree: -

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Title: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Source Genre: Journal
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Publ. Info: London : Royal Society
Pages: - Volume / Issue: 367 (1598) Sequence Number: - Start / End Page: 2023 - 2032 Identifier: ISSN: 0962-8436
CoNE: /journals/resource/963017382021_1