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  Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: A combined MRI, serum marker and gene expression study

Mueller, K., Sacher, J., Arelin, K., Holiga, Š., Kratzsch, J., Villringer, A., et al. (2012). Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: A combined MRI, serum marker and gene expression study. Translational Psychiatry, 2: e200. doi:10.1038/tp.2012.121.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-B9AA-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F3A8-C
Genre: Journal Article

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 Creators:
Mueller, Karsten1, Author              
Sacher, Julia2, 3, Author              
Arelin, Katrin2, 3, 4, Author              
Holiga, Štefan1, Author              
Kratzsch, J.5, Author
Villringer, Arno2, 3, 4, Author              
Schroeter, Matthias L.2, 3, 4, 6, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
6Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              

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Free keywords: Hippocampus; Magnetic resonance imaging; Neuronal injury; Neuron-specific enolase; Obesity
 Abstract: There is growing evidence that obesity represents a risk for enhanced gray matter (GM) density changes comparable to those demonstrated for mild cognitive impairment in the elderly. However, it is not clear what mechanisms underlie this apparent alteration in brain structure of overweight subjects and to what extent these changes can already occur in the adolescent human brain. In the present volumetric magnetic resonance imaging study, we investigated GM changes and serum levels of neuron-specific enolase (NSE), a marker for neuronal injury, in a set of overweight/obese subjects and controls. We report a negative correlation for overweight and obese subjects between serum NSE and GM density in hippocampal and cerebellar regions. To validate our neuroimaging findings, we complement these data with NSE gene expression information obtained from the Allen Brain atlas. GM density changes were localized in brain areas that mediate cognitive function—the hippocampus associated with memory performance, and the cognitive cerebellum (lateral posterior lobes) associated with executive, spatial and linguistic processing. The data of our present study highlight the importance of extending current research on cognitive function and brain plasticity in the elderly in the context of obesity to young adult subjects and include serum biomarkers to validate imaging findings generally.

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Language(s): eng - English
 Dates: 2012-09-172012-08-022012-10-062012-12-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/tp.2012.121
PMID: 23212584
PMC: PMC3565188
 Degree: -

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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 2 Sequence Number: e200 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188