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  Detection and identification of macromolecular complexes in cryo-electron tomograms using support vector machines

Chen, Y., Hrabe, T., Pfeffer, S., Pauly, O., Mateus, D., Navab, N., et al. (2012). Detection and identification of macromolecular complexes in cryo-electron tomograms using support vector machines. In Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium on (pp. 1373-1376). IEEE Xplore.

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 Creators:
Chen, Yuxiang1, Author              
Hrabe, Thomas1, Author              
Pfeffer, Stefan1, Author              
Pauly, Olivier2, Author
Mateus, Diana2, Author
Navab, Nassir2, Author
Förster, Friedrich1, Author              
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
2External Organizations, ou_persistent22              

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Free keywords: Cryo-electron tomography, template matching, support vector machines, spherical harmonics
 Abstract: Detection and identification of macromolecular complexes in cryo-electron tomograms is challenging due to the extremely low signal-to-noise ratio (SNR). While the state-ofthe- art method is template matching with a single template, we propose a 3-step supervised learning approach: (i) predetection of candidates, (ii) feature calculation, and (iii) final decision using a support vector machine (SVM). We use two types of features for SVM: (i) correlation coefficients from multiple templates, and (ii) rotation invariant features derived from spherical harmonics. Experiments conducted on both simulated and experimental tomograms show that our approach outperforms the state-of-the-art method.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1109/ISBI.2012.6235823
 Degree: -

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Title: 9th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro Location
Place of Event: Barcelona, Spain
Start-/End Date: 2012-05-02 - 2012-05-05

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Title: Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium on
  Abbreviation : Biomedical Imaging (ISBI)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: IEEE Xplore
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1373 - 1376 Identifier: ISSN: 1945-7928
ISBN: 978-1-4577-1857-1