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  A Key Role for NF-kappa B Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions

Visekruna, A., Volkov, A., & Steinhoff, U. (2012). A Key Role for NF-kappa B Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 239368. doi:10.1155/2012/239368.

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Genre: Journal Article
Alternative Title : Clin. Dev. Immunol.

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Clin_Dev_Immunol_2012_239868.pdf (Publisher version), 2MB
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Copyright © 2012 Alexander Visekruna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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 Creators:
Visekruna, Alexander1, Author              
Volkov, Anton, Author
Steinhoff, Ulrich1, Author              
Affiliations:
1Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664146              

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 Abstract: The transcription factors of the Rel/NF-kappa B family function as key regulators of innate and adoptive immunity. Tightly and temporally controlled activation of NF-kappa B-signalling pathways ensures prevention of harmful immune cell dysregulation, whereas a loss of control leads to pathological conditions such as severe inflammation, autoimmune disease, and inflammation-associated oncogenesis. Five family members have been identified in mammals: RelA (p65), c-Rel, RelB, and the precursor proteins NF kappa B1 (p105) and NF-kappa B2 (p100), that are processed into p50 and p52, respectively. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T-cell lymphocytes, certain genes essential for immune function such as Il2 and Foxp3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T-cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells (APCs) controls a delicate balance between tolerance and immunity. This review gives a selective overview on recent progress in understanding of diverse roles of c-Rel in regulating adaptive immunity.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 610097
ISI: 000302577300001
DOI: 10.1155/2012/239368
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Title: CLINICAL & DEVELOPMENTAL IMMUNOLOGY
  Alternative Title : Clin. Dev. Immunol.
Source Genre: Journal
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Publ. Info: NEW YORK : HINDAWI PUBLISHING CORPORATION
Pages: - Volume / Issue: - Sequence Number: 239368 Start / End Page: - Identifier: ISSN: 1740-2522