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  Environmental Constraints Guide Migration of Malaria Parasites during Transmission

Hellmann, J. K., Münter, S., Kudryashev, M., Schulz, S., Heiss, K., Müller, A.-K., et al. (2011). Environmental Constraints Guide Migration of Malaria Parasites during Transmission. PLoS Pathogens, 7(6): e1002080. doi:10.1371/journal.ppat.1002080.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-BEF6-D Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-BEF7-B
Genre: Zeitschriftenartikel
Alternativer Titel : PLoS Pathog.

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PLoS_Pathogens_2011_7_e1002080.pdf (Verlagsversion), 2MB
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PLoS_Pathogens_2011_7_e1002080.pdf
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© 2011 Hellmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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 Urheber:
Hellmann, Janina Kristin, Autor
Münter, Sylvia, Autor
Kudryashev, Mikhail, Autor
Schulz, Simon1, Autor
Heiss, Kirsten, Autor
Müller, Ann-Kristin, Autor
Matuschewski, Kai2, Autor           
Spatz, Joachim P.1, Autor
Schwarz, Ulrich S., Autor
Frischknecht, Friedrich, Autor
Affiliations:
1Max Planck Society, ou_persistent13              
2Parasitology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664151              

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 Zusammenfassung: Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue. During transmission of malaria, parasite motility in the skin is important for Plasmodium sporozoites to reach the blood circulation. Here we show that sporozoite migration varies in different skin environments the parasite encounters at the arbitrary sites of the mosquito bite. In order to systematically examine how sporozoite migration depends on the structure of the environment, we studied it in micro-fabricated obstacle arrays. The trajectories observed in vivo and in vitro closely resemble each other suggesting that structural constraints can be sufficient to guide Plasmodium sporozoites in complex environments. Sporozoite speed in different environments is optimized for migration and correlates with persistence length and dispersal. However, this correlation breaks down in mutant sporozoites that show adhesion impairment due to the lack of TRAP-like protein (TLP) on their surfaces. This may explain their delay in infecting the host. The flexibility of sporozoite adaption to different environments and a favorable speed for optimal dispersal ensures efficient host switching duringmalaria transmission.

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Sprache(n): eng - English
 Datum: 2011-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 572774
ISI: 000292379600018
DOI: 10.1371/journal.ppat.1002080
 Art des Abschluß: -

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Titel: PLoS Pathogens
  Alternativer Titel : PLoS Pathog.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: SAN FRANCISCO : PUBLIC LIBRARY SCIENCE
Seiten: - Band / Heft: 7 (6) Artikelnummer: e1002080 Start- / Endseite: - Identifikator: ISSN: 1553-7366