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  Prohibitins Are Required for Cancer Cell Proliferation and Adhesion

Sievers, C., Billig, G., Gottschalk, K., & Rudel, T. (2010). Prohibitins Are Required for Cancer Cell Proliferation and Adhesion. PLoS ONE, 5(9): e12735.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-BF91-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-BF92-5
Genre: Journal Article
Alternative Title : PLoS One

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PLoS_ONE_2010_5_e12735.pdf (Publisher version), 3MB
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Copyright Sievers et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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 Creators:
Sievers, Claudia1, Author              
Billig, Gwendolyn1, Author              
Gottschalk, Kathleen1, Author              
Rudel, Thomas1, Author              
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1Department of Molecular Biology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664147              

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 Abstract: Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane. Although it was originally identified by its ability to inhibit G1/S progression in human fibroblasts, its role as tumor suppressor is debated. To determine the function of prohibitins in maintaining cell homeostasis, we generated cancer cell lines expressing prohibitin-directed shRNAs. We show that prohibitin proteins are necessary for the proliferation of cancer cells. Down-regulation of prohibitin expression drastically reduced the rate of cell division. Furthermore, mitochondrial morphology was not affected, but loss of prohibitins did lead to the degradation of the fusion protein OPA1 and, in certain cancer cell lines, to a reduced capability to exhibit anchorage-independent growth. These cancer cells also exhibited reduced adhesion to the extracellular matrix. Taken together, these observations suggest prohibitins play a crucial role in adhesion processes in the cell and thereby sustaining cancer cell propagation and survival.

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Language(s): eng - English
 Dates: 2010-09-14
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 529504
ISI: 000281815700019
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Title: PLoS ONE
  Alternative Title : PLoS One
Source Genre: Journal
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Pages: - Volume / Issue: 5 (9) Sequence Number: e12735 Start / End Page: - Identifier: ISSN: 1932-6203