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  Rab6 and Rab11 Regulate Chlamydia trachomatis Development and Golgin-84-Dependent Golgi Fragmentation

Lipinski, A. R., Heymann, J., Meissner, C., Karlas, A., Brinkmann, V., Meyer, T. F., et al. (2009). Rab6 and Rab11 Regulate Chlamydia trachomatis Development and Golgin-84-Dependent Golgi Fragmentation. PLoS Pathogens, 5(10): e1000615.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-C097-3 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-C098-1
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PLoS_Pathogens_2009_5_e1000615.pdf (Verlagsversion), 2MB
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© 2009 Rejman Lipinski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Lipinski, Anette Rejman1, Autor              
Heymann, Julia1, Autor              
Meissner, Charlotte1, Autor              
Karlas, Alexander1, Autor              
Brinkmann, Volker2, Autor              
Meyer, Thomas F.1, Autor              
Heuer, Dagmar1, Autor              
Affiliations:
1Department of Molecular Biology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664147              
2Core Facilities / Microscopy, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664142              

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 Zusammenfassung: Many intracellular pathogens that replicate in special membrane bound compartments exploit cellular trafficking pathways by targeting small GTPases, including Rab proteins. Members of the Chlamydiaceae recruit a subset of Rab proteins to their inclusions, but the significance of these interactions is uncertain. Using RNA interference, we identified Rab6 and Rab11 as important regulators of Chlamydia infections. Depletion of either Rab6 or Rab11, but not the other Rab proteins tested, decreased the formation of infectious particles. We further examined the interplay between these Rab proteins and the Golgi matrix components golgin-84 and p115 with regard to Chlamydia-induced Golgi fragmentation. Silencing of the Rab proteins blocked Chlamydia-induced and golgin-84 knockdown-stimulated Golgi disruption, whereas Golgi fragmentation was unaffected in p115 depleted cells. Interestingly, p115-induced Golgi fragmentation could rescue Chlamydia propagation in Rab6 and Rab11 knockdown cells. Furthermore, transport of nutrients to Chlamydia, as monitored by BODIPY-Ceramide, was inhibited by Rab6 and Rab11 knockdown. Taken together, our results demonstrate that Rab6 and Rab11 are key regulators of Golgi stability and further support the notion that Chlamydia subverts Golgi structure to enhance its intracellular development.

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Sprache(n): eng - Englisch
 Datum: 2009-10
 Publikationsstatus: Im Druck publiziert
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 442436
ISI: 000272033300020
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Titel: PLoS Pathogens
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 5 (10) Artikelnummer: e1000615 Start- / Endseite: - Identifikator: ISSN: 1553-7366