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  Role for the Plasmodium sporozoite-specific transmembrane protein S6 in parasite motility and efficient malaria transmission

Steinbüchel, M., & Matuschewski, K. (2009). Role for the Plasmodium sporozoite-specific transmembrane protein S6 in parasite motility and efficient malaria transmission. Cellular Microbiology, 11(2), 279-288.

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Cell_Microbiol_2009_11_279.pdf (Publisher version), 612KB
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Cell_Microbiol_2009_11_279.pdf
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© 2008 The Authors; Journal compilation © 2008 Blackwell Publishing Ltd; Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
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 Creators:
Steinbüchel, Marion, Author
Matuschewski, Kai1, Author           
Affiliations:
1Parasitology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664151              

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Free keywords: TRAP-LIKE PROTEIN; APICOMPLEXAN PARASITES; GLIDING MOTILITY;; SALIVARY-GLANDS; CELL INVASION; MOSQUITO; FALCIPARUM; INFECTION;; BERGHEI; STAGE
 Abstract: Malaria transmission occurs by intradermal deposition of Plasmodium sporozoites during the infectious bite of a female Anopheles mosquito. After formation in midgut-associated oocysts sporozoites actively enter mosquito salivary glands and subsequently invade host hepatocytes where they transform into clinically silent liver stages. To date, two sporozoite-specific transmembrane proteins have been identified that perform vital functions in natural malaria transmission. The sporozoite invasin TRAP drives sporozoite motility and target cell entry whereas the adhesin MAEBL mediates sporozoite recognition of and attachment to salivary glands. Here, we demonstrate that the sporozoite-specific transmembrane protein S6 is required for efficient malaria transmission to the vertebrate host. Targeted deletion of S6 results in severe impairment of sporozoite gliding motility and invasion of mosquito salivary glands. During sporozoite maturation S6 expression is tightly regulated by transcriptional and translational control. We propose that S6 functions together with TRAP/MIC2 family invasins to direct fast, efficient and specific cell entry and, ultimately, life cycle progression of the malaria sporozoite.

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Language(s): eng - English
 Dates: 2009-02
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: eDoc: 440028
ISI: 000262466600009
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Title: Cellular Microbiology
Source Genre: Journal
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Pages: - Volume / Issue: 11 (2) Sequence Number: - Start / End Page: 279 - 288 Identifier: ISSN: 1462-5814 %R 10.1111/j.1462-5822.2008.01252.x