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  Horizontal versus Familial Transmission of Helicobacter pylori

Schwarz, S., Morelli, G., Kusecek, B., Manica, A., Balloux, F., Owen, R. J., et al. (2008). Horizontal versus Familial Transmission of Helicobacter pylori. PLoS Pathogens, 4(10): e1000180.

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Genre: Journal Article
Alternative Title : PLoS Pathog.

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PLoS_Pathogens_2008_4_e1000180.pdf (Publisher version), 432KB
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Copyright: © 2008 Schwarz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Schwarz, Sandra, Author
Morelli, Giovanna1, Author              
Kusecek, Barica1, Author              
Manica, Andrea, Author
Balloux, Francois, Author
Owen, Robert J., Author
Graham, David Y., Author
van der Merwe, Schalk, Author
Achtman, Mark1, Author              
Suerbaum, Sebastian, Author
Affiliations:
1Department of Molecular Biology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664147              

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 Abstract: Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large population samples and to the extensive genetic diversity between isolates, the transmission and spread of H. pylori remain poorly understood. We studied the genetic relationships of H. pylori isolated from 52 individuals of two large families living in a rural community in South Africa and from 43 individuals of 11 families living in urban settings in the United Kingdom, the United States, Korea, and Colombia. A 3,406 bp multilocus sequence haplotype was determined for a total of 142 H. pylori isolates. Isolates were assigned to biogeographic populations, and recent transmission was measured as the occurrence of non-unique isolates, i.e., isolates whose sequences were identical to those of other isolates. Members of urban families were almost always infected with isolates from the biogeographic population that is common in their location. Non-unique isolates were frequent in urban families, consistent with familial transmission between parents and children or between siblings. In contrast, the diversity of H. pylori in the South African families was much more extensive, and four distinct biogeographic populations circulated in this area. Non-unique isolates were less frequent in South African families, and there was no significant correlation between kinship and similarity of H. pylori sequences. However, individuals who lived in the same household did have an increased probability of carrying the same non-unique isolates of H. pylori, independent of kinship. We conclude that patterns of spread of H. pylori under conditions of high prevalence, such as the rural South African families, differ from those in developed countries. Horizontal transmission occurs frequently between persons who do not belong to a core family, blurring the pattern of familial transmission that is typical of developed countries. Predominantly familial transmission in urban societies is likely a result of modern living conditions with good sanitation and where physical contact between persons outside the core family is limited and regulated by societal rules. The patterns observed in rural South African families may be representative of large parts of the developing world.

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Language(s): eng - English
 Dates: 2008-10
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: eDoc: 398374
ISI: 000261481100013
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Title: PLoS Pathogens
  Alternative Title : PLoS Pathog.
Source Genre: Journal
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Pages: - Volume / Issue: 4 (10) Sequence Number: e1000180 Start / End Page: - Identifier: ISSN: 1553-7366